Welcome to Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.

Nobel Prize

Recent Publications

Book: Single-Particle Cryo-Electron Microscopy
Publisher: World Scientific
Editor: Joachim Frank
Click here to order.

Article: On the damage done to the structure of the T. acidophilum
proteasome by electron radiation

Journal: Protein Science
Author: Jimin Wang, et al.

Article: Identification of Changing Ribosome Protein Compositions
using Mass Spectrometry

Journal: Proteomics
Author: Parimal Samir, et al.

Article: Time-Resolved Cryo-electron Microscopy Using a
Microfluidic Chip

Book: Protein Complex Assembly
Author: Sandip Kaledhonkar, et al.

Article: Three-Dimensional Analysis of Mitochondrial Crista Ultrastructure
in a Patient with Leigh Syndrome by In Situ Cryoelectron Tomography

Journal: iScience
Author: Stephanie E. Siegmund, et al.

Article: Single-Particle Reconstruction of Biological Molecules:
Story in a Sample (Nobel Lecture)

Journal: Angewandte Chemie
Author: Joachim Frank

Book chapter: New Insights into Ribosome Structure and Function
Book: Cold Spring Harbor Perspectives in Biology
Author: Amy Jobe, et al.

Article: The Jigsaw Puzzle of mRNA Translation Initiation in Eukaryotes:
A Decade of Structures Unraveling the Mechanics of the Process

Journal: Annual Review of Biophysics
Author: Yaser Hashem, et al.

Article: Cryo-EM shows stages of initial codon selection on the ribosome by
aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A

Journal: Nucleic Acids Research
Author: Marcus Fislage, et al.

Article: Identification of ions in experimental electrostatic
potential maps

Journal: International Union of Crystallography Journal
Author: Jimin Wang, et al.

Recent News

Aaron Klug 1926 - 2018
November 30, 2018

Obituary in the Telegraph: https://www.telegraph.co.uk/obituaries/2018/11/22/aaron-klug-om-physicist-won-nobel-prize-work-electron-microscopy/ Obituary in the Washington Post: https://www.washingtonpost.com/local/obituaries/aaron-klug-nobel-winning-scientist-who-examined-molecular-structure-dies-at-92/2018/11/24/b8a99d4a-ef95-11e8-baac-2a674e91502b_story.html?utm_term=.6bcc7558883a These Obituaries give an idea of the life time achievements and unique intellectual presence of Aaron Klug.  I met him a few times, but these encounters...
New paper in PNAS
Structure and activity of lipid bilayer within a membrane-protein...

Tom Steitz 1940 – 2018
    Tom Steitz was an over-towering...

Paper accepted in Protein Science
On the damage done to the structure of the T. acidophilum...