Welcome to Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.

Recent Publications

Article: Dynamical features of the Plasmodium falciparum ribosome
during translation

Journal: Nucleic Acids Research Journal
Authors: Ming Sun, et al.

Article: Structure of mammalian eIF3 in the context of the 43S
preinitiation complex

Journal: Nature
Authors: Amedee Des Georges, et al.

Article: Structural dynamics of ribosome subunit association studied by
mixing-spraying time-resolved cryo-EM

Journal: Structure
Authors: Bo Chen, et al.

Article: Activation of GTP Hydrolysis in mRNA-tRNA Translocation by
Elongation Factor G

Journal: Science Advances
Authors: Wen Li, et al.

Article: Efficient estimation of three-dimensional covariance and its application
in the analysis of heterogeneous samples in cryo-electron microscopy

Journal: Structure
Authors: Hstau Y. Liao, et al.

Article: CTF Challenge: Result summary
Journal: Journal of Structural Biology
Authors: Roberto Marabini, et al.

Article: Quantitative connection between ensemble thermodynamics and
single-molecule kinetics

Journal: The Journal of Physical Chemistry
Authors: Colin D. Kinz-Thompson, et al.

Article: Structure of a mammalian ryanodine receptor
Journal: Nature
Authors: Ran Zalk, et al.

Article: Trajectories of the ribosome as a Brownian nanomachine
Journal: Proceedings of the National Academy of Sciences of the
United States of America
Authors: Ali Dashti, et al.

Article: Particle migration analysis in iterative classification of cryo-EM
single-particle data

Journal: Journal of Structural Biology
Authors: Bo Chen, et al.

Recent News

Li et al. ribosome-EF-G complex featured in editorial
September 30, 2015

Breaking the Crystal Ceiling: Cryo-electron microscopy goes high resolution. By Erika Gebel Berg ACS Central Science The king and queen of protein structure determination have, for years, been X-ray crystallography and nuclear magnetic resonance spectroscopy. But now there’s a challenger to the throne. This upstart is cryo-electron microscopy (EM)... Click here to read more.
“The Sky Would be the Limit”
In my attempts to make sense of some of the recent...

Paper accepted by Nucleic Acids Research journal
A new paper has just been accepted by NAR journal....

Paper accepted by Nature
A new paper has recently been accepted by Nature–"Structure...