Welcome to Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.

Recent Publications

Article: Dynamical features of the Plasmodium falciparum ribosome
during translation

Journal: Nucleic Acids Research Journal
Authors: Ming Sun, et al.

Article: Structure of mammalian eIF3 in the context of the 43S
preinitiation complex

Journal: Nature
Authors: Amedee Des Georges, et al.

Article: Structural dynamics of ribosome subunit association studied by
mixing-spraying time-resolved cryo-EM

Journal: Structure
Authors: Bo Chen, et al.

Article: Activation of GTP Hydrolysis in mRNA-tRNA Translocation by
Elongation Factor G

Journal: Science Advances
Authors: Wen Li, et al.

Article: Efficient estimation of three-dimensional covariance and its application
in the analysis of heterogeneous samples in cryo-electron microscopy

Journal: Structure
Authors: Hstau Y. Liao, et al.

Article: CTF Challenge: Result summary
Journal: Journal of Structural Biology
Authors: Roberto Marabini, et al.

Article: Quantitative connection between ensemble thermodynamics and
single-molecule kinetics

Journal: The Journal of Physical Chemistry
Authors: Colin D. Kinz-Thompson, et al.

Article: Structure of a mammalian ryanodine receptor
Journal: Nature
Authors: Ran Zalk, et al.

Article: Trajectories of the ribosome as a Brownian nanomachine
Journal: Proceedings of the National Academy of Sciences of the
United States of America
Authors: Ali Dashti, et al.

Article: Particle migration analysis in iterative classification of cryo-EM
single-particle data

Journal: Journal of Structural Biology
Authors: Bo Chen, et al.

Recent News

Paper accepted by Microscopy journal
October 6, 2015

Two promising future developments of cryo-EM: capturing short-lived states and mapping a continuum of states of a macromolecule. Bo Chen and Joachim Frank ABSTRACT: The capabilities and application range of cryogenic electron microscopy (cryo-EM) method have expanded vastly in the last two years, thanks to the advances provided by direct detection devices and computational classification tools. We take this review as an opportunity to sketch out promising developments of cryo-EM in two important directions: (1) imaging of short-lived states...
Li et al. ribosome-EF-G complex featured in editorial
Breaking the Crystal Ceiling: Cryo-electron microscopy...

“The Sky Would be the Limit”
In my attempts to make sense of some of the recent...

Paper accepted by Nucleic Acids Research journal
A new paper has just been accepted by NAR journal....