Welcome to Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.

Recent Publications

Article: Channel opening and gating mechanism in AMPA-subtype
glutamate receptors

Journal: Nature
Authors: Edward C. Twomey, et al.

Article: Structural Bases of Desensitization in AMPA Receptor-Auxiliary
Subunit Complexes

Journal: Neuron
Authors: Edward C. Twomey, et al.

Article: A Fast and Effective Microfluidic Spraying-Plunging Method for High-Resolution Single-Particle Cryo-EM
Journal: Structure
Authors: Xiangsong Feng, et al.

Article: Quantitative Characterization of Domain
Motions in Molecular Machines

Journal: The Journal of Physical Chemistry B
Authors: Suvrajit Maji, et al.

Article: The mechanism of translation
Journal: F1000 Research
Authors: Joachim Frank

Article: Nmd3 is a structural mimic of eIF5A, and activates
the cpGTPase Lsg1 during 60S ribosome biogenesis

Journal: EMBO
Authors: Andrey Malyutin, et al.

Article: Advances in the field of single-particle cryo-electron microscopy
over the last decade

Journal: Nature Protocols
Authors: Joachim Frank

Article: Key Intermediates in Ribosome Recycling Visualized by
Time-Resolved Cryoelectron Microscopy

Journal: Structure
Authors: Ziao Fu, et al.

Article: Determination of the ribosome structure to a resolution of 2.5 Å
by single-particle cryo-EM

Journal: Protein Science
Authors: Zheng Liu, et al.

Article: Structure of the STRA6 receptor for retinol uptake
Journal: Science
Authors: Yunting Chen, et al.

Recent News

Just posted in BioRxiv
July 26, 2017

"Conformational Dynamics and Energy Landscapes of Ligand Binding in RyR1" Ali Dashti, Danya Ben Hail, Ghoncheh Mashayekhi, Peter Schwander, Amedee des Georges, Joachim Frank, Abbas Ourmazd Click here to read. Biorxiv doi: https://doi.org/10.1101/167080 This study uses the technique of Manifold Embedding, introduced into cryo-EM by an earlier article by Dashti et al. (PNAS 2014), to investigate the mechanism of Ryanodine receptor/Calcium release channel activation and gating. A large number of images (about 400,000 of each) for RyR molecules...
New paper in Nature
Channel opening and gating mechanism in AMPA-subtype...

Photos of the new Krios Titan microscope
Click here for the full...

Paper accepted by The Journal of Physical Chemistry
Our paper describing work in collaboration with the late...