Welcome to Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.

Recent Publications

Book: Single-Particle Cryo-Electron Microscopy
Publisher: World Scientific
Editor: Joachim Frank
Click here to order.

Journal: Nature
Author: Sandip Kaledhonkar, et al.

Article: On the damage done to the structure of the T. acidophilum
proteasome by electron radiation

Journal: Protein Science
Author: Jimin Wang, et al.

Article: Identification of Changing Ribosome Protein Compositions
using Mass Spectrometry

Journal: Proteomics
Author: Parimal Samir, et al.

Article: Time-Resolved Cryo-electron Microscopy Using a
Microfluidic Chip

Book: Protein Complex Assembly
Author: Sandip Kaledhonkar, et al.

Article: Three-Dimensional Analysis of Mitochondrial Crista Ultrastructure
in a Patient with Leigh Syndrome by In Situ Cryoelectron Tomography

Journal: iScience
Author: Stephanie E. Siegmund, et al.

Article: Single-Particle Reconstruction of Biological Molecules:
Story in a Sample (Nobel Lecture)

Journal: Angewandte Chemie
Author: Joachim Frank

Book chapter: New Insights into Ribosome Structure and Function
Book: Cold Spring Harbor Perspectives in Biology
Author: Amy Jobe, et al.

Article: The Jigsaw Puzzle of mRNA Translation Initiation in Eukaryotes:
A Decade of Structures Unraveling the Mechanics of the Process

Journal: Annual Review of Biophysics
Author: Yaser Hashem, et al.

Recent News

Hirschegg – old memories from the 1960s.
October 11, 2019

I was recently invited by Michael Roehrl to present a talk at the Memorial Sloan Kettering Institute, here on the East Side of Manhattan. Michael, a physician and researcher at this Institute, is the son of a student I knew from my time in the late 60s at Walter Hoppe’s group, which combined X-ray crystallography with electron microscopy. As a special present Michael gave me pictures of the site of the Hirschegg meetings – early meetings co-organized by Walter Hoppe and Max Perutz in the Austrian Alps. The pictures were sent to him recently...
New paper in Nature
Our paper ‘Late steps in bacterial translation initiation...

Sydney Brenner 1927 – 2019
Sydney Brenner died on April 5 in Singapore at the age of 92. ...

Miloslav (“Milas”) Boublik 1927 - 1994
In my recent talk at the Ribosome meeting in Merida,...