Welcome to Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.

Recent Publications

Article: New Opportunities Created by Single-Particle Cryo-EM:
The Mapping of Conformational Space

Journal: Biochemistry
Author: Joachim Frank

Article: Channel opening and gating mechanism in AMPA-subtype
glutamate receptors

Journal: Nature
Authors: Edward C. Twomey, et al.

Article: Structural Bases of Desensitization in AMPA Receptor-Auxiliary
Subunit Complexes

Journal: Neuron
Authors: Edward C. Twomey, et al.

Article: A Fast and Effective Microfluidic Spraying-Plunging Method for High-Resolution Single-Particle Cryo-EM
Journal: Structure
Authors: Xiangsong Feng, et al.

Article: Quantitative Characterization of Domain
Motions in Molecular Machines

Journal: The Journal of Physical Chemistry B
Authors: Suvrajit Maji, et al.

Article: The mechanism of translation
Journal: F1000 Research
Authors: Joachim Frank

Article: Nmd3 is a structural mimic of eIF5A, and activates
the cpGTPase Lsg1 during 60S ribosome biogenesis

Journal: EMBO
Authors: Andrey Malyutin, et al.

Article: Advances in the field of single-particle cryo-electron microscopy
over the last decade

Journal: Nature Protocols
Authors: Joachim Frank

Article: Key Intermediates in Ribosome Recycling Visualized by
Time-Resolved Cryoelectron Microscopy

Journal: Structure
Authors: Ziao Fu, et al.

Article: Determination of the ribosome structure to a resolution of 2.5 Å
by single-particle cryo-EM

Journal: Protein Science
Authors: Zheng Liu, et al.

Recent News

Günter Blobel (May 21, 1936 – February 18, 2018)
February 20, 2018

Günter Blobel was a German biologist born in Silesia, which is now part of Poland. He received the 1999 Nobel Prize in Physiology and Medicine for the discovery that proteins have intrinsic signals – Zip code-like -- that govern their transport and localization in the cell. Following his pioneering biochemical discoveries on signaling he postulated the existence of a “translocon,” a pore in the ER membrane specialized to receive polypeptides from the ribosome and translocate them into the ER or assist them to fold and become a membrane-intrinsic...
Donald Parsons
Donald Parsons passed away earlier this month at age 89. He established...

Ross Smith
On Saturday, Dec 16, our dear friend and colleague...

Nobel Prize ceremony and more
  Click the links below to watch all of the Nobel...