Welcome to Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.

Recent Publications

Article: Structure and assembly model for the Trypanosoma cruzi 60S
ribosomal subunit

Journal: PNAS
Authors: Zheng Liu, et al.

Article: Structural Basis for Gating and Activation of RyR1
Journal: Cell
Authors: Amédée des Georges, et al.

Article: Elucidation of AMPA receptor–stargazin complexes by
cryo–electron microscopy

Journal: Science
Authors: Edward C. Twomey, et al.

Article: Whither Ribosome Structure and Dynamics Research?
(A Perspective)

Journal: Journal of Molecular Biology
Authors: Joachim Frank

Article: Continuous Changes in Structure Mapped by Manifold Embedding
of Single-Particle Data in Cryo-EM

Journal: Methods
Authors: Joachim Frank, Abbas Ourmazd

Article: Generalized single-particle cryo-EM – a historical perspective
Journal: Microscopy
Authors: Joachim Frank

Article: Dynamical features of the Plasmodium falciparum ribosome
during translation

Journal: Nucleic Acids Research Journal
Authors: Ming Sun, et al.

Article: Structure of mammalian eIF3 in the context of the 43S
preinitiation complex

Journal: Nature
Authors: Amedee Des Georges, et al.

Article: Structural dynamics of ribosome subunit association studied by
mixing-spraying time-resolved cryo-EM

Journal: Structure
Authors: Bo Chen, et al.

Article: Activation of GTP Hydrolysis in mRNA-tRNA Translocation by
Elongation Factor G

Journal: Science Advances
Authors: Wen Li, et al.

Recent News

New paper in PNAS
October 11, 2016

Our paper describing the 2.5-Å structure of the large ribosomal subunit of T. cruzi has finally appeared. It presents a culmination of a collaboration of four groups: our own lab, Susan Madison Antennucci’s at the Wadsworth Center in Albany, Liang Tong’s at the Department of Biological Sciences, also Columbia University, and John Woolford’s at Carnegie Mellon University in Pittsburgh. “Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit.” Zheng Liu, Cristina Gutierrez-Vargas, Jia Wei, Robert A. Grassucci,...
Structural Basis for Gating and Activation of RyR1
Our long-awaited Cell article on the activation and gating...

Congratulations Dr. Ming Sun
Congratulations to Dr. Ming Sun for her successful...

New paper accepted by Cell
Structural basis for gating and activation of RyR1. by...