Welcome to Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.

Nobel Prize

Recent Publications

Book: Single-Particle Cryo-Electron Microscopy
Publisher: World Scientific
Editor: Joachim Frank
Click here to order.

Article: On the damage done to the structure of the T. acidophilum
proteasome by electron radiation

Journal: Protein Science
Author: Jimin Wang, et al.

Article: Identification of Changing Ribosome Protein Compositions
using Mass Spectrometry

Journal: Proteomics
Author: Parimal Samir, et al.

Article: Time-Resolved Cryo-electron Microscopy Using a
Microfluidic Chip

Book: Protein Complex Assembly
Author: Sandip Kaledhonkar, et al.

Article: Three-Dimensional Analysis of Mitochondrial Crista Ultrastructure
in a Patient with Leigh Syndrome by In Situ Cryoelectron Tomography

Journal: iScience
Author: Stephanie E. Siegmund, et al.

Article: Single-Particle Reconstruction of Biological Molecules:
Story in a Sample (Nobel Lecture)

Journal: Angewandte Chemie
Author: Joachim Frank

Book chapter: New Insights into Ribosome Structure and Function
Book: Cold Spring Harbor Perspectives in Biology
Author: Amy Jobe, et al.

Article: The Jigsaw Puzzle of mRNA Translation Initiation in Eukaryotes:
A Decade of Structures Unraveling the Mechanics of the Process

Journal: Annual Review of Biophysics
Author: Yaser Hashem, et al.

Article: Cryo-EM shows stages of initial codon selection on the ribosome by
aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A

Journal: Nucleic Acids Research
Author: Marcus Fislage, et al.

Article: Identification of ions in experimental electrostatic
potential maps

Journal: International Union of Crystallography Journal
Author: Jimin Wang, et al.

Recent News

Sydney Brenner 1927 – 2019
April 6, 2019

Sydney Brenner died on April 5 in Singapore at the age of 92.  Brenner has been called a giant of molecular biology.  Among his many contributions to this field are key experiments in 1961 proving that the mRNA is the carrier of genetic information, and the substrate for protein synthesis on the ribosome.   Here I want to focus on his role in the discovery of mRNA, for obvious reasons.  The question who discovered mRNA is complicated as it involves many people, at a time when there was still confusion about...
Miloslav (“Milas”) Boublik 1927 - 1994
In my recent talk at the Ribosome meeting in Merida,...

Aaron Klug 1926 - 2018
Obituary in the Telegraph: https://www.telegraph.co.uk/obituaries/2018/11/22/aaron-klug-om-physicist-won-nobel-prize-work-electron-microscopy/ Obituary...

New paper in PNAS
Structure and activity of lipid bilayer within a membrane-protein...