Welcome to the Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.
 


Recent Publications



Book: Found in Translation: Collection of Original Articles on Single-Particle Reconstruction and the Structural Basis of
Protein Synthesis

Publisher: World Scientific
[Description]

Book: Computational Methods for Three-Dimensional
Microscopy Reconstruction

Editors: Garbor T. Herman, Joachim Frank
Publisher: Springer
[Description]

Article: Exploring the dynamics of supramolecular machines with
cryo-electron microscopy

Journal: International Solvay Institutes
Author: Joachim Frank
[Introduction]

Article: EttA regulates translation by binding to the ribosomal E site and restricting ribosome-tRNA dynamics
Journal: Nature Structural & Molecular Biology
Author: Bo Chen, et al.
[Abstract]

Article: The ABC-F protein EttA gates ribosome entry into the translation elongation cycle
Journal: Nature Structural & Molecular Biology
Author: Grégory Boël, et al.
[Abstract]

Article: Structure of the mammalian ribosomal pre-termination complex associated with eRF1•eRF3•GDPNP
Journal: Nucleic Acids Research
Author: Amédée des Georges, et al.
[Abstract]

Article: Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to
gain access to the 40S subunit

Journal: Nature
Author: Yaser Hashem, et al.
[Abstract]

Article: Cryo-EM visualization of the ribosome in termination complex
with apo-RF3 and RF1

Journal: eLife
Author: Jesper Pallesen, et al.
[Abstract]

Article: Structure of the mammalian ribosomal 43S preinitiation complex
bound to the scanning factor DHX29

Journal: Cell
Author: Yaser Hashem, et al.
[Summary]

Article: Story in a sample – the potential (and limitations) of cryo-electron microscopy applied to molecular machines
Journal: Biopolymers
Author: Joachim Frank
[Introduction]


Recent News


New paper in Nucleic Acids Research journal
February 4, 2014

Structure of the mammalian ribosomal pre-termination complex associated with eRF1•eRF3•GDPNP des Georges, A., Hashem, Y., Unbehaun, A., Grassucci, R.A., Taylor, D., Hellen, C.U.T., Pestova, T.V., and Frank, J. Abstract: Eukaryotic translation termination results from the complex functional interplay between two release factors, eRF1 and eRF3, in which GTP hydrolysis by eRF3 couples codon recognition with peptidyl-tRNA hydrolysis by eRF1. Here, we present a cryo-electron microscopy structure of pre-termination complexes associated with...
Forthcoming book: Found In Translation
FOUND IN TRANSLATION Selected Papers by Joachim Frank...

Solvay Institute archival letters
During my attendance of the 2013 Solvay Conference...

Franklin Institute Award announcement
The Franklin Institute has just announced that Joachim...