Welcome to Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.

Recent Publications

Article: Channel opening and gating mechanism in AMPA-subtype
glutamate receptors

Journal: Nature
Authors: Edward C. Twomey, et al.

Article: Structural Bases of Desensitization in AMPA Receptor-Auxiliary
Subunit Complexes

Journal: Neuron
Authors: Edward C. Twomey, et al.

Article: A Fast and Effective Microfluidic Spraying-Plunging Method for High-Resolution Single-Particle Cryo-EM
Journal: Structure
Authors: Xiangsong Feng, et al.

Article: Quantitative Characterization of Domain
Motions in Molecular Machines

Journal: The Journal of Physical Chemistry B
Authors: Suvrajit Maji, et al.

Article: The mechanism of translation
Journal: F1000 Research
Authors: Joachim Frank

Article: Nmd3 is a structural mimic of eIF5A, and activates
the cpGTPase Lsg1 during 60S ribosome biogenesis

Journal: EMBO
Authors: Andrey Malyutin, et al.

Article: Advances in the field of single-particle cryo-electron microscopy
over the last decade

Journal: Nature Protocols
Authors: Joachim Frank

Article: Key Intermediates in Ribosome Recycling Visualized by
Time-Resolved Cryoelectron Microscopy

Journal: Structure
Authors: Ziao Fu, et al.

Article: Determination of the ribosome structure to a resolution of 2.5 Å
by single-particle cryo-EM

Journal: Protein Science
Authors: Zheng Liu, et al.

Article: Structure of the STRA6 receptor for retinol uptake
Journal: Science
Authors: Yunting Chen, et al.

Recent News

Donald Parsons
December 31, 2017

Donald Parsons passed away earlier this month at age 89. He established high-voltage electron microscopy at the Division of Labs and Research of the New York State Department of Health in Albany, later to be renamed Wadsworth Center. Parsons was convinced that most cancers were caused by viruses, and that the reason they had not been found was a sampling problem. Imaging whole cells in 3D with 1MV electrons would be a way to find them. Parsons hired me in 1975 to establish an image processing group. The high-voltage microscope was still in crates...
Ross Smith
On Saturday, Dec 16, our dear friend and colleague...

Nobel Prize ceremony and more
  Click the links below to watch all of the Nobel...

2017 Nobel Prize in Chemistry
Interview on Spiegel TV: Click here for press...