Welcome to Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.
 


Recent Publications



Article: Structural Bases of Desensitization in AMPA Receptor-Auxiliary
Subunit Complexes

Journal: Neuron
Authors: Edward C. Twomey, et al.
[Abstract]

Article: A Fast and Effective Microfluidic Spraying-Plunging Method for High-Resolution Single-Particle Cryo-EM
Journal: Structure
Authors: Xiangsong Feng, et al.
[Abstract]

Article: Quantitative Characterization of Domain
Motions in Molecular Machines

Journal: The Journal of Physical Chemistry B
Authors: Suvrajit Maji, et al.
[Abstract]

Article: The mechanism of translation
Journal: F1000 Research
Authors: Joachim Frank
[Abstract]

Article: Nmd3 is a structural mimic of eIF5A, and activates
the cpGTPase Lsg1 during 60S ribosome biogenesis

Journal: EMBO
Authors: Andrey Malyutin, et al.
[Abstract]

Article: Advances in the field of single-particle cryo-electron microscopy
over the last decade

Journal: Nature Protocols
Authors: Joachim Frank
[Abstract]

Article: Key Intermediates in Ribosome Recycling Visualized by
Time-Resolved Cryoelectron Microscopy

Journal: Structure
Authors: Ziao Fu, et al.
[Abstract]

Article: Determination of the ribosome structure to a resolution of 2.5 Å
by single-particle cryo-EM

Journal: Protein Science
Authors: Zheng Liu, et al.
[Abstract]

Article: Structure of the STRA6 receptor for retinol uptake
Journal: Science
Authors: Yunting Chen, et al.
[Abstract]

Article: Structure and assembly model for the Trypanosoma cruzi 60S
ribosomal subunit

Journal: PNAS
Authors: Zheng Liu, et al.
[Abstract]


Recent News


Photos of the new Krios Titan microscope
April 25, 2017

Click here for the full Dropbox gallery.
Paper accepted by The Journal of Physical Chemistry
Our paper describing work in collaboration with the late...

Paper accepted by Structure
An article describing the design and testing of a new PDMS-based...

Just accepted by EMBO Journal
Title: Nmd3 is a structural mimic of eIF5A, and activates...