Welcome to Frank Lab
We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.
Recent Publications
Book: Single-Particle Cryo-Electron MicroscopyPublisher: World Scientific
Editor: Joachim Frank
Click here to order.
[Description]
Book chapter: New Insights into Ribosome Structure and Function
Book: Cold Spring Harbor Perspectives in Biology
Author: Amy Jobe, et al.
[Introduction]
Article: The Jigsaw Puzzle of mRNA Translation Initiation in Eukaryotes:
A Decade of Structures Unraveling the Mechanics of the Process
Journal: Annual Review of Biophysics
Author: Yaser Hashem, et al.
[Abstract]
Article: Cryo-EM shows stages of initial codon selection on the ribosome by
aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A
Journal: Nucleic Acids Research
Author: Marcus Fislage, et al.
[Abstract]
Article: Identification of ions in experimental electrostatic
potential maps
Journal: International Union of Crystallography Journal
Author: Jimin Wang, et al.
[Abstract]
Article: New Opportunities Created by Single-Particle Cryo-EM:
The Mapping of Conformational Space
Journal: Biochemistry
Author: Joachim Frank
[Preview]
Article: Channel opening and gating mechanism in AMPA-subtype
glutamate receptors
Journal: Nature
Authors: Edward C. Twomey, et al.
[Abstract]
Article: Structural Bases of Desensitization in AMPA Receptor-Auxiliary
Subunit Complexes
Journal: Neuron
Authors: Edward C. Twomey, et al.
[Abstract]
Article: A Fast and Effective Microfluidic Spraying-Plunging Method for High-Resolution Single-Particle Cryo-EM
Journal: Structure
Authors: Xiangsong Feng, et al.
[Abstract]
Article: Quantitative Characterization of Domain
Motions in Molecular Machines
Journal: The Journal of Physical Chemistry B
Authors: Suvrajit Maji, et al.
[Abstract]
Recent News
Top downloaded article in Protein Science
June 19, 2018
Determination of the ribosome structure to a resolution of 2.5 Å by single-particle cryo-EM, published in Protein Science, was one of the journal’s top 20 most downloaded recent papers!*
As of year-end 2017 the article has received 1832 downloads.
* Comparative exercise based on measuring downloads within the first 12 months of online publication, for articles published between 2016-2017
