Welcome to Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.
 


Recent Publications



Book: Single-Particle Cryo-Electron Microscopy
Publisher: World Scientific
Editor: Joachim Frank
Click here to order.
[Description]

Journal: Nature
Author: Sandip Kaledhonkar, et al.

Article: On the damage done to the structure of the T. acidophilum
proteasome by electron radiation

Journal: Protein Science
Author: Jimin Wang, et al.
[Abstract]

Article: Identification of Changing Ribosome Protein Compositions
using Mass Spectrometry

Journal: Proteomics
Author: Parimal Samir, et al.
[Abstract]

Article: Time-Resolved Cryo-electron Microscopy Using a
Microfluidic Chip

Book: Protein Complex Assembly
Author: Sandip Kaledhonkar, et al.
[Abstract]

Article: Three-Dimensional Analysis of Mitochondrial Crista Ultrastructure
in a Patient with Leigh Syndrome by In Situ Cryoelectron Tomography

Journal: iScience
Author: Stephanie E. Siegmund, et al.
[Summary]

Article: Single-Particle Reconstruction of Biological Molecules:
Story in a Sample (Nobel Lecture)

Journal: Angewandte Chemie
Author: Joachim Frank
[Background]

Book chapter: New Insights into Ribosome Structure and Function
Book: Cold Spring Harbor Perspectives in Biology
Author: Amy Jobe, et al.
[Introduction]

Article: The Jigsaw Puzzle of mRNA Translation Initiation in Eukaryotes:
A Decade of Structures Unraveling the Mechanics of the Process

Journal: Annual Review of Biophysics
Author: Yaser Hashem, et al.
[Abstract]


Recent News


The Electron Microscope – from a Sketch in 1931 to Reality
December 26, 2019

A sketch circulated by Pablo Guerra Lahoz on Twitter prompted me to put together this brief chronicle of the invention that has changed our lives in so many ways. What I didn’t realize was that Ernst Ruska started his studies at the Technical University Munich in 1929, where I got my Ph.D. in 1970. He went to the Technical University of Berlin in 1927 where he finished his Ph.D. in 1933. He hypothesized that electrons with their much smaller wavelength could be used to image objects with much higher resolution than light microscopes. The sketch...
Hirschegg – old memories from the 1960s.
I was recently invited by Michael Roehrl to present...

New paper in Nature
Our paper ‘Late steps in bacterial translation initiation...

Sydney Brenner 1927 – 2019
Sydney Brenner died on April 5 in Singapore at the age of 92. ...