Welcome to Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.
 


Recent Publications



Article: Generalized single-particle cryo-EM – a historical perspective
Journal: Microscopy
Authors: Joachim Frank
[Abstract]

Article: Dynamical features of the Plasmodium falciparum ribosome
during translation

Journal: Nucleic Acids Research Journal
Authors: Ming Sun, et al.
[Abstract]

Article: Structure of mammalian eIF3 in the context of the 43S
preinitiation complex

Journal: Nature
Authors: Amedee Des Georges, et al.
[Abstract]

Article: Structural dynamics of ribosome subunit association studied by
mixing-spraying time-resolved cryo-EM

Journal: Structure
Authors: Bo Chen, et al.
[Abstract]

Article: Activation of GTP Hydrolysis in mRNA-tRNA Translocation by
Elongation Factor G

Journal: Science Advances
Authors: Wen Li, et al.
[Abstract]

Article: Efficient estimation of three-dimensional covariance and its application
in the analysis of heterogeneous samples in cryo-electron microscopy

Journal: Structure
Authors: Hstau Y. Liao, et al.
[Abstract]

Article: CTF Challenge: Result summary
Journal: Journal of Structural Biology
Authors: Roberto Marabini, et al.
[Abstract]

Article: Quantitative connection between ensemble thermodynamics and
single-molecule kinetics

Journal: The Journal of Physical Chemistry
Authors: Colin D. Kinz-Thompson, et al.
[Abstract]

Article: Structure of a mammalian ryanodine receptor
Journal: Nature
Authors: Ran Zalk, et al.
[Abstract]

Article: Trajectories of the ribosome as a Brownian nanomachine
Journal: Proceedings of the National Academy of Sciences of the
United States of America
Authors: Ali Dashti, et al.
[Significance]


Recent News


Article accepted to Methods
February 12, 2016

The Article “Continuous Changes in Structure Mapped by Manifold Embedding of Single-Particle Data in Cryo-EM” authored by Joachim Frank and Abbas Ourmazd has been accepted by the journal Methods. ABSTRACT: Cryo-electron microscopy, when combined with single-particle reconstruction, is a powerful method for studying macromolecular structure. Recent developments in detector technology have pushed the resolution into a range comparable to that of X-ray crystallography. However, cryo-EM is able to separate and thus recover the structure of each...
New paper in Microscopy
Another article by Frank Lab has been published in Microscopy...

Plasmodium paper featured on Columbia website
Frank Lab's recent paper in Nucleic Acids Research...

Paper accepted by Microscopy journal
Two promising future developments of cryo-EM: capturing...