July 26, 2017
"Conformational Dynamics and Energy Landscapes of Ligand Binding in RyR1"
Ali Dashti, Danya Ben Hail, Ghoncheh Mashayekhi, Peter Schwander, Amedee des Georges, Joachim Frank, Abbas Ourmazd
Click here to read. Biorxiv doi: https://doi.org/10.1101/167080
This study uses the technique of Manifold Embedding, introduced into cryo-EM by an earlier article by Dashti et al. (PNAS 2014), to investigate the mechanism of Ryanodine receptor/Calcium release channel activation and gating. A large number of images (about 400,000 of each) for RyR molecules...