Welcome to Frank Lab
We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.
Recent Publications
Book: Single-Particle Cryo-Electron MicroscopyPublisher: World Scientific
Editor: Joachim Frank
Click here to order.
[Description]
Article: On the damage done to the structure of the T. acidophilum
proteasome by electron radiation
Journal: Protein Science
Author: Jimin Wang, et al.
[Abstract]
Article: Identification of Changing Ribosome Protein Compositions
using Mass Spectrometry
Journal: Proteomics
Author: Parimal Samir, et al.
[Abstract]
Article: Time-Resolved Cryo-electron Microscopy Using a
Microfluidic Chip
Book: Protein Complex Assembly
Author: Sandip Kaledhonkar, et al.
[Abstract]
Article: Three-Dimensional Analysis of Mitochondrial Crista Ultrastructure
in a Patient with Leigh Syndrome by In Situ Cryoelectron Tomography
Journal: iScience
Author: Stephanie E. Siegmund, et al.
[Summary]
Article: Single-Particle Reconstruction of Biological Molecules:
Story in a Sample (Nobel Lecture)
Journal: Angewandte Chemie
Author: Joachim Frank
[Background]
Book chapter: New Insights into Ribosome Structure and Function
Book: Cold Spring Harbor Perspectives in Biology
Author: Amy Jobe, et al.
[Introduction]
Article: The Jigsaw Puzzle of mRNA Translation Initiation in Eukaryotes:
A Decade of Structures Unraveling the Mechanics of the Process
Journal: Annual Review of Biophysics
Author: Yaser Hashem, et al.
[Abstract]
Article: Cryo-EM shows stages of initial codon selection on the ribosome by
aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A
Journal: Nucleic Acids Research
Author: Marcus Fislage, et al.
[Abstract]
Article: Identification of ions in experimental electrostatic
potential maps
Journal: International Union of Crystallography Journal
Author: Jimin Wang, et al.
[Abstract]
Recent News
New paper in Nature
May 19, 2019
Our paper ‘Late steps in bacterial translation initiation visualized using time-resolved cryo-EM' by Kaledhonkar et al. has been scheduled for Accelerated Article Preview (AAP) on http://www.nature.com/nature on 20 May 2019 at 1600 London time / 1100 US Eastern Time.
ABSTRACT. Bacterial translation initiation entails the tightly regulated joining of the 50S ribosomal subunit to an initiator transfer RNA (fMet-tRNAfMet)-containing 30S ribosomal initiation complex (IC) to form a 70S IC that subsequently matures into a 70S elongation-competent...
