Welcome to Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.
 


Recent Publications



Book: Single-Particle Cryo-Electron Microscopy
Publisher: World Scientific
Editor: Joachim Frank
Click here to order.
[Description]

Journal: Journal of Chemical Information and Modeling
Author: Evan Seitz, Joachim Frank
[Abstract]

Journal: Nature
Author: Sandip Kaledhonkar, et al.

Article: On the damage done to the structure of the T. acidophilum
proteasome by electron radiation

Journal: Protein Science
Author: Jimin Wang, et al.
[Abstract]

Article: Identification of Changing Ribosome Protein Compositions
using Mass Spectrometry

Journal: Proteomics
Author: Parimal Samir, et al.
[Abstract]

Article: Time-Resolved Cryo-electron Microscopy Using a
Microfluidic Chip

Book: Protein Complex Assembly
Author: Sandip Kaledhonkar, et al.
[Abstract]

Article: Three-Dimensional Analysis of Mitochondrial Crista Ultrastructure
in a Patient with Leigh Syndrome by In Situ Cryoelectron Tomography

Journal: iScience
Author: Stephanie E. Siegmund, et al.
[Summary]

Article: Single-Particle Reconstruction of Biological Molecules:
Story in a Sample (Nobel Lecture)

Journal: Angewandte Chemie
Author: Joachim Frank
[Background]

Book chapter: New Insights into Ribosome Structure and Function
Book: Cold Spring Harbor Perspectives in Biology
Author: Amy Jobe, et al.
[Introduction]


Recent News


A Brief Guide to Three Papers from Our Group Related to Structural Heterogeneity
April 3, 2020

Structural heterogeneity has been long recognized as a problem for structure research by cryo-EM. Different molecule species, or molecules in different conformational states or binding configurations may co-exist. Without resolving this heterogeneity, reconstructions are blurred, and are invalid as representations of any one physical structure. Existing, widely used approaches to resolving heterogeneity, such as Relion, are based on the assumption that the structure exists in a few discrete conformations. Beginning with a paper we published jointly...
The Indian Statistical Institute in Calcutta
  Prasanta Chandra Mahalanobis1893 – 1972       I...

The Electron Microscope – from a Sketch in 1931 to Reality
A sketch circulated by Pablo Guerra Lahoz on Twitter...

Hirschegg – old memories from the 1960s.
I was recently invited by Michael Roehrl to present...