November 18, 2015
Another article by Frank Lab has been published in Microscopy journal.
Generalized single-particle cryo-EM – a historical perspective.
By Joachim Frank.
ABSTRACT: This is a brief account of the earlier history of single-particle cryo-EM of biological molecules lacking internal symmetry, which goes back to the mid-seventies. The emphasis of this review is on the mathematical concepts and computational approaches. It is written as the field experiences a turning point in the wake of the introduction of digital cameras capable of single electron...