Welcome to Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.
 

Nobel Prize


Recent Publications



Book: Single-Particle Cryo-Electron Microscopy
Publisher: World Scientific
Editor: Joachim Frank
Click here to order.
[Description]

Book chapter: New Insights into Ribosome Structure and Function
Book: Cold Spring Harbor Perspectives in Biology
Author: Amy Jobe, et al.
[Introduction]

Article: The Jigsaw Puzzle of mRNA Translation Initiation in Eukaryotes:
A Decade of Structures Unraveling the Mechanics of the Process

Journal: Annual Review of Biophysics
Author: Yaser Hashem, et al.
[Abstract]

Article: Cryo-EM shows stages of initial codon selection on the ribosome by
aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A

Journal: Nucleic Acids Research
Author: Marcus Fislage, et al.
[Abstract]

Article: Identification of ions in experimental electrostatic
potential maps
Journal: International Union of Crystallography Journal
Author: Jimin Wang, et al.
[Abstract]

Article: New Opportunities Created by Single-Particle Cryo-EM:
The Mapping of Conformational Space

Journal: Biochemistry
Author: Joachim Frank
[Preview]

Article: Channel opening and gating mechanism in AMPA-subtype
glutamate receptors

Journal: Nature
Authors: Edward C. Twomey, et al.
[Abstract]

Article: Structural Bases of Desensitization in AMPA Receptor-Auxiliary
Subunit Complexes

Journal: Neuron
Authors: Edward C. Twomey, et al.
[Abstract]

Article: A Fast and Effective Microfluidic Spraying-Plunging Method for High-Resolution Single-Particle Cryo-EM
Journal: Structure
Authors: Xiangsong Feng, et al.
[Abstract]

Article: Quantitative Characterization of Domain
Motions in Molecular Machines

Journal: The Journal of Physical Chemistry B
Authors: Suvrajit Maji, et al.
[Abstract]


Recent News


Top downloaded article in Protein Science
June 19, 2018

Determination of the ribosome structure to a resolution of 2.5 Å by single-particle cryo-EM, published in Protein Science, was one of the journal’s top 20 most downloaded recent papers!* As of year-end 2017 the article has received 1832 downloads. * Comparative exercise based on measuring downloads within the first 12 months of online publication, for articles published between 2016-2017
Featured in Columbia Medicine magazine
A Nobel Recognizes a Cool Scientific Method (Pun...

Cold Spring Harbor Perspectives, Chapter in press
New Insights into Ribosome Structure and Function Amy...

Nucleic Acids Research paper in press
Cryo-EM shows stages of initial codon selection on the ribosome...