Welcome to the Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.

Recent Publications

Article: Structure of a mammalian ryanodine receptor
Journal: Nature
Author: Ran Zalk, et al.

Article: Trajectories of the ribosome as a Brownian nanomachine
Journal: Proceedings of the National Academy of Sciences of the
United States of America
Author: Ali Dashti, et al.

Article: Particle migration analysis in iterative classification of cryo-EM
single-particle data

Journal: Journal of Structural Biology
Author: Bo Chen, et al.

Article: Automated particle picking for low-contrast macromolecules in cryo-electron microscopy
Journal: Journal of Structural Biology
Author: Robert Langlois, et al.

Article: Exploring the dynamics of supramolecular machines with
cryo-electron microscopy

Journal: International Solvay Institutes
Author: Joachim Frank

Article: EttA regulates translation by binding to the ribosomal E site and restricting ribosome-tRNA dynamics
Journal: Nature Structural & Molecular Biology
Author: Bo Chen, et al.

Article: The ABC-F protein EttA gates ribosome entry into the translation elongation cycle
Journal: Nature Structural & Molecular Biology
Author: Grégory Boël, et al.

Article: Structure of the mammalian ribosomal pre-termination complex associated with eRF1•eRF3•GDPNP
Journal: Nucleic Acids Research
Author: Amédée des Georges, et al.

Article: Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to
gain access to the 40S subunit

Journal: Nature
Author: Yaser Hashem, et al.

Article: Cryo-EM visualization of the ribosome in termination complex
with apo-RF3 and RF1

Journal: eLife
Author: Jesper Pallesen, et al.

Recent News

Ensemble thermodynamics & Single-molecule kinetics
March 19, 2015

Our manuscript entitled "Quantitative Connection Between Ensemble Thermodynamics and Single-Molecule Kinetics: A Case Study Using Cryo-EM and smFRET Investigations of the Ribosome" Authors: Kinz-Thompson, Colin; Sharma, Ajeet; Frank, Joachim; Gonzalez, Ruben; Chowdhury, Debashish has just been accepted by The Journal of Physical Chemistry Part: Part B: Biophysical Chemistry, Biomaterials, Liquids, and Soft Matter This study was spurred by the fact that intermediate states of the pretranslocational complex of the ribosome were found by cryo-EM...
The Ryanodine receptor
The Ryanodine receptor (calcium release channel)...

Energy Landscape computed by analyzing single-particle cryo-EM images of ~850,000 ribosomes purified from yeast
The picture shows the result of a novel method of analysis,...

Happy birthday, Dr. Frank!
Frank Lab celebrated with pizza at Antika.