February 12, 2016
The Article “Continuous Changes in Structure Mapped by Manifold Embedding of Single-Particle Data in Cryo-EM” authored by Joachim Frank and Abbas Ourmazd has been accepted by the journal Methods.
Cryo-electron microscopy, when combined with single-particle reconstruction, is a powerful method for studying macromolecular structure. Recent developments in detector technology have pushed the resolution into a range comparable to that of X-ray crystallography. However, cryo-EM is able to separate and thus recover the structure of each...