December 12, 2013
Structure of the mammalian ribosomal pre-termination complex associated with eRF1•eRF3•GDPNP
des Georges, A., Hashem, Y., Unbehaun, A., Grassucci, R.A., Taylor, D., Hellen, C.U.T., Pestova, T.V.,
and Frank, J.
Eukaryotic translation termination results from the complex functional interplay between two release factors, eRF1 and eRF3, in which GTP hydrolysis by eRF3 couples codon recognition with peptidyl-tRNA hydrolysis by eRF1. Here, we present a cryo-electron microscopy structure of pre-termination complexes associated with...