Welcome to the Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.
 


Recent Publications



Article: Structural dynamics of ribosome subunit association studied by
mixing-spraying time-resolved cryo-EM

Journal: Structure
Authors: Bo Chen, et al.
[Abstract]

Article: Activation of GTP Hydrolysis in mRNA-tRNA Translocation by
Elongation Factor G

Journal: Science Advances
Authors: Wen Li, et al.
[Abstract]

Article: Efficient estimation of three-dimensional covariance and its application
in the analysis of heterogeneous samples in cryo-electron microscopy

Journal: Structure
Authors: Hstau Y. Liao, et al.
[Abstract]

Article: CTF Challenge: Result summary
Journal: Journal of Structural Biology
Authors: Roberto Marabini, et al.
[Abstract]

Article: Quantitative connection between ensemble thermodynamics and
single-molecule kinetics

Journal: The Journal of Physical Chemistry
Authors: Colin D. Kinz-Thompson, et al.
[Abstract]

Article: Structure of a mammalian ryanodine receptor
Journal: Nature
Authors: Ran Zalk, et al.
[Abstract]

Article: Trajectories of the ribosome as a Brownian nanomachine
Journal: Proceedings of the National Academy of Sciences of the
United States of America
Authors: Ali Dashti, et al.
[Significance]

Article: Particle migration analysis in iterative classification of cryo-EM
single-particle data

Journal: Journal of Structural Biology
Authors: Bo Chen, et al.
[Abstract]

Article: Automated particle picking for low-contrast macromolecules in cryo-electron microscopy
Journal: Journal of Structural Biology
Authors: Robert Langlois, et al.
[Abstract]

Article: Exploring the dynamics of supramolecular machines with
cryo-electron microscopy

Journal: International Solvay Institutes
Author: Joachim Frank
[Introduction]


Recent News


Structure's June 2015 cover and Q&A
June 15, 2015

The June 2015 cover of Structure is an illustration by Melissa Thomas-Baum and Hstau Y. Liao. It accompanies this article published in the same issue: Liao, H.Y., Hashem, Y., and Frank, J. (2015). Efficient estimation of three-dimensional covariance and its application in the analysis of heterogeneous samples in cryo-electron microscopy. Structure 23, 1129–1137. The journal has launched a new blog named "Biology in 3D" to open it up to more people and teach them about the importance of structural biology. In their latest post, senior editor,...
Advances in 3D covariance estimation
The real-space 3D covariance estimation we published...

“Time-resolved study of ribosome subunit association”
accepted by Structure
A paper entitled “Structural dynamics of ribosome...

Paper accepted by Science Advances
Our manuscript entitled “Activation of GTP Hydrolysis...