Welcome to Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.

Recent Publications

Article: Advances in the field of single-particle cryo-electron microscopy
over the last decade

Journal: Nature Protocols
Authors: Joachim Frank

Article: Key Intermediates in Ribosome Recycling Visualized by
Time-Resolved Cryoelectron Microscopy

Journal: Structure
Authors: Ziao Fu, et al.

Article: Determination of the ribosome structure to a resolution of 2.5 Å
by single-particle cryo-EM

Journal: Protein Science
Authors: Zheng Liu, et al.

Article: Structure of the STRA6 receptor for retinol uptake
Journal: Science
Authors: Yunting Chen, et al.

Article: Structure and assembly model for the Trypanosoma cruzi 60S
ribosomal subunit

Journal: PNAS
Authors: Zheng Liu, et al.

Article: Structural Basis for Gating and Activation of RyR1
Journal: Cell
Authors: Amédée des Georges, et al.

Article: Elucidation of AMPA receptor–stargazin complexes by
cryo–electron microscopy

Journal: Science
Authors: Edward C. Twomey, et al.

Article: Whither Ribosome Structure and Dynamics Research?
(A Perspective)

Journal: Journal of Molecular Biology
Authors: Joachim Frank

Article: Continuous Changes in Structure Mapped by Manifold Embedding
of Single-Particle Data in Cryo-EM

Journal: Methods
Authors: Joachim Frank, Abbas Ourmazd

Article: Generalized single-particle cryo-EM – a historical perspective
Journal: Microscopy
Authors: Joachim Frank

Recent News

John Desmond Bernal
January 11, 2017

In Tallahassee, Florida, I had the privilege to participate in the 90th birthday celebration for Don Caspar, as I will report in another note. Andrew Brown, the last speaker of that Symposium organized at Florida State University gave a historical account of J D Bernal, a physicist who crossed paths with Don early on and must have been quite influential for his thinking. Now what interested me greatly is that Bernal, as early as 1931, well before the discovery of the structure of DNA (1953 by James Watson and Francis Crick), well before the structure...
The Beam is On!
The new Krios Titan of Columbia University has just...

New article in Nature Protocols
Advances in the field of single-particle cryo-electron...

Commentary to Structure, Fu et al.
Following termination of protein synthesis, bacterial...