Welcome to Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.
 


Recent Publications



Article: Continuous Changes in Structure Mapped by Manifold Embedding
of Single-Particle Data in Cryo-EM

Journal: Methods
Authors: Joachim Frank, Abbas Ourmazd
[Abstract]

Article: Generalized single-particle cryo-EM – a historical perspective
Journal: Microscopy
Authors: Joachim Frank
[Abstract]

Article: Dynamical features of the Plasmodium falciparum ribosome
during translation

Journal: Nucleic Acids Research Journal
Authors: Ming Sun, et al.
[Abstract]

Article: Structure of mammalian eIF3 in the context of the 43S
preinitiation complex

Journal: Nature
Authors: Amedee Des Georges, et al.
[Abstract]

Article: Structural dynamics of ribosome subunit association studied by
mixing-spraying time-resolved cryo-EM

Journal: Structure
Authors: Bo Chen, et al.
[Abstract]

Article: Activation of GTP Hydrolysis in mRNA-tRNA Translocation by
Elongation Factor G

Journal: Science Advances
Authors: Wen Li, et al.
[Abstract]

Article: Efficient estimation of three-dimensional covariance and its application
in the analysis of heterogeneous samples in cryo-electron microscopy

Journal: Structure
Authors: Hstau Y. Liao, et al.
[Abstract]

Article: CTF Challenge: Result summary
Journal: Journal of Structural Biology
Authors: Roberto Marabini, et al.
[Abstract]

Article: Quantitative connection between ensemble thermodynamics and
single-molecule kinetics

Journal: The Journal of Physical Chemistry
Authors: Colin D. Kinz-Thompson, et al.
[Abstract]

Article: Structure of a mammalian ryanodine receptor
Journal: Nature
Authors: Ran Zalk, et al.
[Abstract]


Recent News


Article in Methods
April 25, 2016

The article “Continuous Changes in Structure Mapped by Manifold Embedding of Single-Particle Data in Cryo-EM” authored by Joachim Frank and Abbas Ourmazd has been accepted by the journal Methods. ABSTRACT: Cryo-electron microscopy, when combined with single-particle reconstruction, is a powerful method for studying macromolecular structure. Recent developments in detector technology have pushed the resolution into a range comparable to that of X-ray crystallography. However, cryo-EM is able to separate and thus recover the structure of each...
Dr. Knud Nierhaus
Knud Nierhaus passed away a few days ago. He is remembered...

Dr. Walter Hoppe
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Ewen Callaway’s News Feature in Nature on September...