Welcome to the Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.

Recent Publications

Article: Structure of a mammalian ryanodine receptor
Journal: Nature
Author: Ran Zalk, et al.

Article: Trajectories of the ribosome as a Brownian nanomachine
Journal: Proceedings of the National Academy of Sciences of the
United States of America
Author: Ali Dashti, et al.

Article: Particle migration analysis in iterative classification of cryo-EM
single-particle data

Journal: Journal of Structural Biology
Author: Bo Chen, et al.

Article: Automated particle picking for low-contrast macromolecules in cryo-electron microscopy
Journal: Journal of Structural Biology
Author: Robert Langlois, et al.

Article: Exploring the dynamics of supramolecular machines with
cryo-electron microscopy

Journal: International Solvay Institutes
Author: Joachim Frank

Article: EttA regulates translation by binding to the ribosomal E site and restricting ribosome-tRNA dynamics
Journal: Nature Structural & Molecular Biology
Author: Bo Chen, et al.

Article: The ABC-F protein EttA gates ribosome entry into the translation elongation cycle
Journal: Nature Structural & Molecular Biology
Author: Grégory Boël, et al.

Article: Structure of the mammalian ribosomal pre-termination complex associated with eRF1•eRF3•GDPNP
Journal: Nucleic Acids Research
Author: Amédée des Georges, et al.

Article: Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to
gain access to the 40S subunit

Journal: Nature
Author: Yaser Hashem, et al.

Article: Cryo-EM visualization of the ribosome in termination complex
with apo-RF3 and RF1

Journal: eLife
Author: Jesper Pallesen, et al.

Recent News

The Ryanodine receptor
February 5, 2015

The Ryanodine receptor (calcium release channel) is the largest ion channel whose structure has been solved. It is also the largest membrane protein. The structure was solved at 4.5Å resolution through a collaboration between three prominent labs at the Columbia Medical Center: the labs of Andew Marks (leading expert on ryanodine receptor), Wayne Hendrickson (leading expert on structural biology) and Joachim Frank’s lab (leading expert on cryo-EM). Years of efforts by X-ray crystallography have been unsuccessful, with the best crystal...
Energy Landscape computed by analyzing single-particle cryo-EM images of ~850,000 ribosomes purified from yeast
The picture shows the result of a novel method of analysis,...

Happy birthday, Dr. Frank!
Frank Lab celebrated with pizza at Antika.

NRAMM 2014 Workshop
The National Resource for Automated Molecular Microscopy...