Welcome to Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.

Nobel Prize

Recent Publications

Book: Single-Particle Cryo-Electron Microscopy
Publisher: World Scientific
Editor: Joachim Frank
Click here to order.

Article: On the damage done to the structure of the T. acidophilum
proteasome by electron radiation

Journal: Protein Science
Author: Jimin Wang, et al.

Article: Identification of Changing Ribosome Protein Compositions
using Mass Spectrometry

Journal: Proteomics
Author: Parimal Samir, et al.

Article: Time-Resolved Cryo-electron Microscopy Using a
Microfluidic Chip

Book: Protein Complex Assembly
Author: Sandip Kaledhonkar, et al.

Article: Three-Dimensional Analysis of Mitochondrial Crista Ultrastructure
in a Patient with Leigh Syndrome by In Situ Cryoelectron Tomography

Journal: iScience
Author: Stephanie E. Siegmund, et al.

Article: Single-Particle Reconstruction of Biological Molecules:
Story in a Sample (Nobel Lecture)

Journal: Angewandte Chemie
Author: Joachim Frank

Book chapter: New Insights into Ribosome Structure and Function
Book: Cold Spring Harbor Perspectives in Biology
Author: Amy Jobe, et al.

Article: The Jigsaw Puzzle of mRNA Translation Initiation in Eukaryotes:
A Decade of Structures Unraveling the Mechanics of the Process

Journal: Annual Review of Biophysics
Author: Yaser Hashem, et al.

Article: Cryo-EM shows stages of initial codon selection on the ribosome by
aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A

Journal: Nucleic Acids Research
Author: Marcus Fislage, et al.

Article: Identification of ions in experimental electrostatic
potential maps

Journal: International Union of Crystallography Journal
Author: Jimin Wang, et al.

Recent News

New paper in PNAS
November 6, 2018

Structure and Activity of Lipid Bilayer within a Membrane Protein Transporter Weihua Qiu, Ziao Fu, Guoyan G. Xu, Robert A. Grassucci, Yan Zhang, Joachim Frank, Wayne A. Hendrickson, Youzhong Guo PNAS Abstract: Membrane proteins function in native cell membranes, but extraction into isolated particles is needed for many biochemical and structural analyses.  Commonly used detergent-extraction methods destroy naturally associated lipid bilayers. Here, we devised a detergent-free method for preparing cell membrane nanoparticles to study the multidrug...
Tom Steitz 1940 – 2018
    Tom Steitz was an over-towering...

Paper accepted in Protein Science
On the damage done to the structure of the T. acidophilum...

Artifacts in the Nobel Museum, Stockholm
Featured in the guided tours. On the left is the back-illuminated...