Welcome to Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.

Recent Publications

Book: Single-Particle Cryo-Electron Microscopy
Publisher: World Scientific
Editor: Joachim Frank
Click here to order.

Journal: Nature
Author: Sandip Kaledhonkar, et al.

Article: On the damage done to the structure of the T. acidophilum
proteasome by electron radiation

Journal: Protein Science
Author: Jimin Wang, et al.

Article: Identification of Changing Ribosome Protein Compositions
using Mass Spectrometry

Journal: Proteomics
Author: Parimal Samir, et al.

Article: Time-Resolved Cryo-electron Microscopy Using a
Microfluidic Chip

Book: Protein Complex Assembly
Author: Sandip Kaledhonkar, et al.

Article: Three-Dimensional Analysis of Mitochondrial Crista Ultrastructure
in a Patient with Leigh Syndrome by In Situ Cryoelectron Tomography

Journal: iScience
Author: Stephanie E. Siegmund, et al.

Article: Single-Particle Reconstruction of Biological Molecules:
Story in a Sample (Nobel Lecture)

Journal: Angewandte Chemie
Author: Joachim Frank

Book chapter: New Insights into Ribosome Structure and Function
Book: Cold Spring Harbor Perspectives in Biology
Author: Amy Jobe, et al.

Article: The Jigsaw Puzzle of mRNA Translation Initiation in Eukaryotes:
A Decade of Structures Unraveling the Mechanics of the Process

Journal: Annual Review of Biophysics
Author: Yaser Hashem, et al.

Recent News

The Indian Statistical Institute in Calcutta
January 24, 2020

  Prasanta Chandra Mahalanobis1893 – 1972       I recently was invited by the Indian Statistical Institute in Calcutta to give the convocation address (see http://franxfiction.com/convocation-speech-at-indian-statistical-institute-jan-23-2020/). I learned the Institute was founded in 1931 by Mahalanobis, whose name rings a bell since I was familiar with the distance measure he introduced. Wikipedia: “The Mahalanobis distance is a measure of the distance between a point P and a distribution D, introduced by P. C. Mahalanobis in 1936. It is a multi-dimensional...
The Electron Microscope – from a Sketch in 1931 to Reality
A sketch circulated by Pablo Guerra Lahoz on Twitter...

Hirschegg – old memories from the 1960s.
I was recently invited by Michael Roehrl to present...

New paper in Nature
Our paper ‘Late steps in bacterial translation initiation...