Welcome to Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.
 


Recent Publications



Article: Continuous Changes in Structure Mapped by Manifold Embedding
of Single-Particle Data in Cryo-EM

Journal: Methods
Authors: Joachim Frank, Abbas Ourmazd
[Abstract]

Article: Generalized single-particle cryo-EM – a historical perspective
Journal: Microscopy
Authors: Joachim Frank
[Abstract]

Article: Dynamical features of the Plasmodium falciparum ribosome
during translation

Journal: Nucleic Acids Research Journal
Authors: Ming Sun, et al.
[Abstract]

Article: Structure of mammalian eIF3 in the context of the 43S
preinitiation complex

Journal: Nature
Authors: Amedee Des Georges, et al.
[Abstract]

Article: Structural dynamics of ribosome subunit association studied by
mixing-spraying time-resolved cryo-EM

Journal: Structure
Authors: Bo Chen, et al.
[Abstract]

Article: Activation of GTP Hydrolysis in mRNA-tRNA Translocation by
Elongation Factor G

Journal: Science Advances
Authors: Wen Li, et al.
[Abstract]

Article: Efficient estimation of three-dimensional covariance and its application
in the analysis of heterogeneous samples in cryo-electron microscopy

Journal: Structure
Authors: Hstau Y. Liao, et al.
[Abstract]

Article: CTF Challenge: Result summary
Journal: Journal of Structural Biology
Authors: Roberto Marabini, et al.
[Abstract]

Article: Quantitative connection between ensemble thermodynamics and
single-molecule kinetics

Journal: The Journal of Physical Chemistry
Authors: Colin D. Kinz-Thompson, et al.
[Abstract]

Article: Structure of a mammalian ryanodine receptor
Journal: Nature
Authors: Ran Zalk, et al.
[Abstract]


Recent News


New paper by Israel Fernandez
May 16, 2016

Congratulations to Israel Fernandez for the publication of his new article in eLife, together with Venki Ramakrishnan: ”Structural characterization of ribosome recruitment and translocation by type IV IRES” Click here to read.
Article in Methods
The article “Continuous Changes in Structure Mapped...

Dr. Knud Nierhaus
Knud Nierhaus passed away a few days ago. He is remembered...

Dr. Walter Hoppe
Walter Hoppe (March 21, 1917 – November 3, 1986) Archives...