Welcome to Frank Lab
We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.
Recent Publications
Article: Channel opening and gating mechanism in AMPA-subtype
glutamate receptors
Journal: Nature
Authors: Edward C. Twomey, et al.
[Abstract]
Article: Structural Bases of Desensitization in AMPA Receptor-Auxiliary
Subunit Complexes
Journal: Neuron
Authors: Edward C. Twomey, et al.
[Abstract]
Article: A Fast and Effective Microfluidic Spraying-Plunging Method for High-Resolution Single-Particle Cryo-EM
Journal: Structure
Authors: Xiangsong Feng, et al.
[Abstract]
Article: Quantitative Characterization of Domain
Motions in Molecular Machines
Journal: The Journal of Physical Chemistry B
Authors: Suvrajit Maji, et al.
[Abstract]
Article: Nmd3 is a structural mimic of eIF5A, and activates
the cpGTPase Lsg1 during 60S ribosome biogenesis
Journal: EMBO
Authors: Andrey Malyutin, et al.
[Abstract]
Article: Advances in the field of single-particle cryo-electron microscopy
over the last decade
Journal: Nature Protocols
Authors: Joachim Frank
[Abstract]
Article: Key Intermediates in Ribosome Recycling Visualized by
Time-Resolved Cryoelectron Microscopy
Journal: Structure
Authors: Ziao Fu, et al.
[Abstract]
Article: Determination of the ribosome structure to a resolution of 2.5 Å
by single-particle cryo-EM
Journal: Protein Science
Authors: Zheng Liu, et al.
[Abstract]
Article: Structure of the STRA6 receptor for retinol uptake
Journal: Science
Authors: Yunting Chen, et al.
[Abstract]
Recent News
Just posted in BioRxiv
July 26, 2017
"Conformational Dynamics and Energy Landscapes of Ligand Binding in RyR1"
Ali Dashti, Danya Ben Hail, Ghoncheh Mashayekhi, Peter Schwander, Amedee des Georges, Joachim Frank, Abbas Ourmazd
Click here to read. Biorxiv doi: https://doi.org/10.1101/167080
This study uses the technique of Manifold Embedding, introduced into cryo-EM by an earlier article by Dashti et al. (PNAS 2014), to investigate the mechanism of Ryanodine receptor/Calcium release channel activation and gating. A large number of images (about 400,000 of each) for RyR molecules...
