Welcome to Frank Lab
We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.
Recent Publications
Book: Single-Particle Cryo-Electron MicroscopyPublisher: World Scientific
Editor: Joachim Frank
Click here to order.
[Description]
Article: On the damage done to the structure of the T. acidophilum
proteasome by electron radiation
Journal: Protein Science
Author: Jimin Wang, et al.
[Abstract]
Article: Identification of Changing Ribosome Protein Compositions
using Mass Spectrometry
Journal: Proteomics
Author: Parimal Samir, et al.
[Abstract]
Article: Time-Resolved Cryo-electron Microscopy Using a
Microfluidic Chip
Book: Protein Complex Assembly
Author: Sandip Kaledhonkar, et al.
[Abstract]
Article: Three-Dimensional Analysis of Mitochondrial Crista Ultrastructure
in a Patient with Leigh Syndrome by In Situ Cryoelectron Tomography
Journal: iScience
Author: Stephanie E. Siegmund, et al.
[Summary]
Article: Single-Particle Reconstruction of Biological Molecules:
Story in a Sample (Nobel Lecture)
Journal: Angewandte Chemie
Author: Joachim Frank
[Background]
Book chapter: New Insights into Ribosome Structure and Function
Book: Cold Spring Harbor Perspectives in Biology
Author: Amy Jobe, et al.
[Introduction]
Article: The Jigsaw Puzzle of mRNA Translation Initiation in Eukaryotes:
A Decade of Structures Unraveling the Mechanics of the Process
Journal: Annual Review of Biophysics
Author: Yaser Hashem, et al.
[Abstract]
Article: Cryo-EM shows stages of initial codon selection on the ribosome by
aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A
Journal: Nucleic Acids Research
Author: Marcus Fislage, et al.
[Abstract]
Article: Identification of ions in experimental electrostatic
potential maps
Journal: International Union of Crystallography Journal
Author: Jimin Wang, et al.
[Abstract]
Recent News
Aaron Klug 1926 - 2018
November 30, 2018
Obituary in the Telegraph:
https://www.telegraph.co.uk/obituaries/2018/11/22/aaron-klug-om-physicist-won-nobel-prize-work-electron-microscopy/
Obituary in the Washington Post:
https://www.washingtonpost.com/local/obituaries/aaron-klug-nobel-winning-scientist-who-examined-molecular-structure-dies-at-92/2018/11/24/b8a99d4a-ef95-11e8-baac-2a674e91502b_story.html?utm_term=.6bcc7558883a
These Obituaries give an idea of the life time achievements and unique intellectual presence of Aaron Klug. I met him a few times, but these encounters...
