Welcome to Frank Lab
We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.
Recent Publications
Book: Single-Particle Cryo-Electron MicroscopyPublisher: World Scientific
Editor: Joachim Frank
Click here to order.
[Description]
Article: Identification of ions in experimental electrostatic
potential maps
Journal: International Union of Crystallography Journal
Author: Jimin Wang, et al.
[Abstract]
Article: New Opportunities Created by Single-Particle Cryo-EM:
The Mapping of Conformational Space
Journal: Biochemistry
Author: Joachim Frank
[Preview]
Article: Channel opening and gating mechanism in AMPA-subtype
glutamate receptors
Journal: Nature
Authors: Edward C. Twomey, et al.
[Abstract]
Article: Structural Bases of Desensitization in AMPA Receptor-Auxiliary
Subunit Complexes
Journal: Neuron
Authors: Edward C. Twomey, et al.
[Abstract]
Article: A Fast and Effective Microfluidic Spraying-Plunging Method for High-Resolution Single-Particle Cryo-EM
Journal: Structure
Authors: Xiangsong Feng, et al.
[Abstract]
Article: Quantitative Characterization of Domain
Motions in Molecular Machines
Journal: The Journal of Physical Chemistry B
Authors: Suvrajit Maji, et al.
[Abstract]
Article: Nmd3 is a structural mimic of eIF5A, and activates
the cpGTPase Lsg1 during 60S ribosome biogenesis
Journal: EMBO
Authors: Andrey Malyutin, et al.
[Abstract]
Article: Advances in the field of single-particle cryo-electron microscopy
over the last decade
Journal: Nature Protocols
Authors: Joachim Frank
[Abstract]
Recent News
Paper accepted to IUCrJ
April 19, 2018
Identification of ions in experimental electrostatic potential maps.
Jimin Wang, Zheng Liu, Joachim Frank and Peter Moore.
International Union of Crystallography Journal
ABSTRACT
Cryo-electron microscopy (EM) directly images the distribution of electrostatic potential
within macromolecules, and thus can provide much more information about atomic
charges than X-ray crystallography normally does. The electron scattering length of an
isolated ion is quite different from that of the corresponding neutral atom. The difference
is very large...
