Welcome to Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.
 


Recent Publications



Article: Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase
Lsg1 during 60S ribosome biogenesis

Journal: EMBO
Authors: Andrey Malyutin, et al.
[Abstract]

Article: Advances in the field of single-particle cryo-electron microscopy
over the last decade

Journal: Nature Protocols
Authors: Joachim Frank
[Abstract]

Article: Key Intermediates in Ribosome Recycling Visualized by
Time-Resolved Cryoelectron Microscopy

Journal: Structure
Authors: Ziao Fu, et al.
[Abstract]

Article: Determination of the ribosome structure to a resolution of 2.5 Å
by single-particle cryo-EM

Journal: Protein Science
Authors: Zheng Liu, et al.
[Abstract]

Article: Structure of the STRA6 receptor for retinol uptake
Journal: Science
Authors: Yunting Chen, et al.
[Abstract]

Article: Structure and assembly model for the Trypanosoma cruzi 60S
ribosomal subunit

Journal: PNAS
Authors: Zheng Liu, et al.
[Abstract]

Article: Structural Basis for Gating and Activation of RyR1
Journal: Cell
Authors: Amédée des Georges, et al.
[Abstract]

Article: Elucidation of AMPA receptor–stargazin complexes by
cryo–electron microscopy

Journal: Science
Authors: Edward C. Twomey, et al.
[Abstract]

Article: Whither Ribosome Structure and Dynamics Research?
(A Perspective)

Journal: Journal of Molecular Biology
Authors: Joachim Frank
[Abstract]

Article: Continuous Changes in Structure Mapped by Manifold Embedding
of Single-Particle Data in Cryo-EM

Journal: Methods
Authors: Joachim Frank, Abbas Ourmazd
[Abstract]


Recent News


Paper accepted by The Journal of Physical Chemistry
February 15, 2017

Our paper describing work in collaboration with the late Klaus Schulten, “Quantitative Characterization of Domain Motions in Molecular Machines” by Suvrajit Maji, Rezvan Shahoei, Klaus Schulten and Joachim Frank, has just been accepted by  The Journal of Physical Chemistry Part B -- Biophysical Chemistry, Biomaterials, Liquids, and Soft Matter.  It will appear in a Special Issue dedicated to the memory of Klaus Schulten.   ABSTRACT The work of molecular machines such as the ribosome is accompanied by conformational changes, often...
Paper accepted by Structure
An article describing the design and testing of a new PDMS-based...

Just accepted by EMBO Journal
Title: Nmd3 is a structural mimic of eIF5A, and activates...

Don Caspar's 90th Birthday Symposium
JANUARY 7-8, 2017 at Florida State University, Tallahassee “Don...