Welcome to Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.
 

Nobel Prize


Recent Publications



Book: Single-Particle Cryo-Electron Microscopy
Publisher: World Scientific
Editor: Joachim Frank
Click here to order.
[Description]

Article: Time-Resolved Cryo-electron Microscopy Using a
Microfluidic Chip

Book: Protein Complex Assembly
Author: Sandip Kaledhonkar, et al.
[Abstract]

Article: Three-Dimensional Analysis of Mitochondrial Crista Ultrastructure
in a Patient with Leigh Syndrome by In Situ Cryoelectron Tomography

Journal: iScience
Author: Stephanie E. Siegmund, et al.
[Summary]

Article: Single-Particle Reconstruction of Biological Molecules:
Story in a Sample (Nobel Lecture)

Journal: Angewandte Chemie
Author: Joachim Frank
[Background]

Book chapter: New Insights into Ribosome Structure and Function
Book: Cold Spring Harbor Perspectives in Biology
Author: Amy Jobe, et al.
[Introduction]

Article: The Jigsaw Puzzle of mRNA Translation Initiation in Eukaryotes:
A Decade of Structures Unraveling the Mechanics of the Process

Journal: Annual Review of Biophysics
Author: Yaser Hashem, et al.
[Abstract]

Article: Cryo-EM shows stages of initial codon selection on the ribosome by
aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A

Journal: Nucleic Acids Research
Author: Marcus Fislage, et al.
[Abstract]

Article: Identification of ions in experimental electrostatic
potential maps

Journal: International Union of Crystallography Journal
Author: Jimin Wang, et al.
[Abstract]

Article: New Opportunities Created by Single-Particle Cryo-EM:
The Mapping of Conformational Space

Journal: Biochemistry
Author: Joachim Frank
[Preview]

Article: Channel opening and gating mechanism in AMPA-subtype
glutamate receptors

Journal: Nature
Authors: Edward C. Twomey, et al.
[Abstract]


Recent News


New paper on bioRxiv
August 14, 2018

Real-time structural dynamics of late steps in bacterial translation initiation visualized using time-resolved cryogenic electron microscopy Sandip Kaledhonkar, Ziao Fu, Kelvin Caban, Wen Li, Bo Chen, Ming Sun, Ruben L. Gonzalez Jr., Joachim Frank ABSTRACT Bacterial translation initiation entails the tightly regulated joining of the 50S ribosomal subunit to an initiator transfer RNA (fMet-tRNAfMet)-containing 30S ribosomal initiation complex (IC) to form a 70S IC that subsequently matures into a 70S elongation-competent complex...
Ken Downing 1949 - 2017
It was with great sadness that I heard that Ken has passed...

New paper in iScience
Three-Dimensional Analysis of Mitochondrial Crista...

Physics in Frankfurt
In Frankfurt, where I was recently on the occasion...