Welcome to the Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.

Recent Publications

Article: CTF Challenge: Result summary
Journal: Journal of Structural Biology
Author: Roberto Marabini, et al.

Article: Quantitative connection between ensemble thermodynamics and
single-molecule kinetics

Journal: The Journal of Physical Chemistry
Author: Colin D. Kinz-Thompson, et al.

Article: Structure of a mammalian ryanodine receptor
Journal: Nature
Author: Ran Zalk, et al.

Article: Trajectories of the ribosome as a Brownian nanomachine
Journal: Proceedings of the National Academy of Sciences of the
United States of America
Author: Ali Dashti, et al.

Article: Particle migration analysis in iterative classification of cryo-EM
single-particle data

Journal: Journal of Structural Biology
Author: Bo Chen, et al.

Article: Automated particle picking for low-contrast macromolecules in cryo-electron microscopy
Journal: Journal of Structural Biology
Author: Robert Langlois, et al.

Article: Exploring the dynamics of supramolecular machines with
cryo-electron microscopy

Journal: International Solvay Institutes
Author: Joachim Frank

Article: EttA regulates translation by binding to the ribosomal E site and restricting ribosome-tRNA dynamics
Journal: Nature Structural & Molecular Biology
Author: Bo Chen, et al.

Article: The ABC-F protein EttA gates ribosome entry into the translation elongation cycle
Journal: Nature Structural & Molecular Biology
Author: Grégory Boël, et al.

Article: Structure of the mammalian ribosomal pre-termination complex associated with eRF1•eRF3•GDPNP
Journal: Nucleic Acids Research
Author: Amédée des Georges, et al.

Recent News

“Time-resolved study of ribosome subunit association”
accepted by Structure
April 8, 2015

A paper entitled “Structural dynamics of ribosome subunit association studied by mixing-spraying time-resolved cryo-EM” by Bo Chen, Sandip Kaledhonkar, Ming Sun, Bingxin Shen, Zonghuan Lu, David Barnard, Toh-Ming Lu, Ruben L. Gonzalez Jr., and Joachim Frank has just been accepted by the journal Structure. The study follows the reaction at time points 60 and 140 milliseconds, and two several minutes long controls. Contentious questions to be answered were: At what time are bridges formed? Does the association reaction follow kinetic predictions?...
Paper accepted by Science Advances
Our manuscript entitled “Activation of GTP Hydrolysis...

Ensemble thermodynamics & Single-molecule kinetics
Our manuscript entitled "Quantitative Connection...

The Ryanodine receptor
The Ryanodine receptor (calcium release channel)...