Welcome to Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.

Recent Publications

Article: Key Intermediates in Ribosome Recycling Visualized by
Time-Resolved Cryoelectron Microscopy

Journal: Structure
Authors: Ziao Fu, et al.

Article: Determination of the ribosome structure to a resolution of 2.5 Å
by single-particle cryo-EM

Journal: Protein Science
Authors: Zheng Liu, et al.

Article: Structure of the STRA6 receptor for retinol uptake
Journal: Science
Authors: Yunting Chen, et al.

Article: Structure and assembly model for the Trypanosoma cruzi 60S
ribosomal subunit

Journal: PNAS
Authors: Zheng Liu, et al.

Article: Structural Basis for Gating and Activation of RyR1
Journal: Cell
Authors: Amédée des Georges, et al.

Article: Elucidation of AMPA receptor–stargazin complexes by
cryo–electron microscopy

Journal: Science
Authors: Edward C. Twomey, et al.

Article: Whither Ribosome Structure and Dynamics Research?
(A Perspective)

Journal: Journal of Molecular Biology
Authors: Joachim Frank

Article: Continuous Changes in Structure Mapped by Manifold Embedding
of Single-Particle Data in Cryo-EM

Journal: Methods
Authors: Joachim Frank, Abbas Ourmazd

Article: Generalized single-particle cryo-EM – a historical perspective
Journal: Microscopy
Authors: Joachim Frank

Article: Dynamical features of the Plasmodium falciparum ribosome
during translation

Journal: Nucleic Acids Research Journal
Authors: Ming Sun, et al.

Recent News

Klaus Schulten
November 3, 2016

I was very sad to hear that Klaus Schulten passed away on November 1 after several months of illness. He was an enthusiastic collaborator and friend for more than a decade. We had just submitted a joint paper on a general method of describing domain motions in molecular machines for the Festschrift planned for the celebration of his 70th birthday. Our earlier collaborations, in which his students Elizabeth Villa and Leonardo Trabuco played a key role, focused on the atomic modeling of the ribosome and on the development of a general modeling tool...
New paper in PNAS
Our paper describing the 2.5-Å structure of the large...

Structural Basis for Gating and Activation of RyR1
Our long-awaited Cell article on the activation and gating...

Congratulations Dr. Ming Sun
Congratulations to Dr. Ming Sun for her successful...