Welcome to Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.

Recent Publications

Article: Elucidation of AMPA receptor–stargazin complexes by
cryo–electron microscopy

Journal: Science
Authors: Edward C. Twomey, et al.

Article: Whither Ribosome Structure and Dynamics Research?
(A Perspective)

Journal: Journal of Molecular Biology
Authors: Joachim Frank

Article: Continuous Changes in Structure Mapped by Manifold Embedding
of Single-Particle Data in Cryo-EM

Journal: Methods
Authors: Joachim Frank, Abbas Ourmazd

Article: Generalized single-particle cryo-EM – a historical perspective
Journal: Microscopy
Authors: Joachim Frank

Article: Dynamical features of the Plasmodium falciparum ribosome
during translation

Journal: Nucleic Acids Research Journal
Authors: Ming Sun, et al.

Article: Structure of mammalian eIF3 in the context of the 43S
preinitiation complex

Journal: Nature
Authors: Amedee Des Georges, et al.

Article: Structural dynamics of ribosome subunit association studied by
mixing-spraying time-resolved cryo-EM

Journal: Structure
Authors: Bo Chen, et al.

Article: Activation of GTP Hydrolysis in mRNA-tRNA Translocation by
Elongation Factor G

Journal: Science Advances
Authors: Wen Li, et al.

Article: Efficient estimation of three-dimensional covariance and its application
in the analysis of heterogeneous samples in cryo-electron microscopy

Journal: Structure
Authors: Hstau Y. Liao, et al.

Article: CTF Challenge: Result summary
Journal: Journal of Structural Biology
Authors: Roberto Marabini, et al.

Recent News

Congratulations Dr. Ming Sun
July 19, 2016

Congratulations to Dr. Ming Sun for her successful thesis defense on Thursday, July 14, 2016. The title of her Ph.D. thesis is “Cryo-Electron Microscopy Studies of Dynamical Features of Ribosomes During the Translation Process.” Members of her Thesis Committee: Ruben Gonzalez (Chair), Joachim Frank (Sponsor/Mentor), Wayne Hendrickson, Bridget Carragher, and Jeffrey Dvorin (Children’s Hospital, Harvard Medical School)
New paper accepted by Cell
Structural basis for gating and activation of RyR1. by...

New paper in Science
Elucidation of AMPA receptor–stargazin complexes...

Jingji Zhang receives PhD
Congratulations to Jingji Zhang on receiving his PhD....