Welcome to Frank Lab

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.
 

Nobel Prize


Recent Publications



Book: Single-Particle Cryo-Electron Microscopy
Publisher: World Scientific
Editor: Joachim Frank
Click here to order.
[Description]

Book chapter: New Insights into Ribosome Structure and Function
Book: Cold Spring Harbor Perspectives in Biology
Author: Amy Jobe, et al.
[Introduction]

Article: The Jigsaw Puzzle of mRNA Translation Initiation in Eukaryotes:
A Decade of Structures Unraveling the Mechanics of the Process

Journal: Annual Review of Biophysics
Author: Yaser Hashem, et al.
[Abstract]

Article: Cryo-EM shows stages of initial codon selection on the ribosome by
aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A

Journal: Nucleic Acids Research
Author: Marcus Fislage, et al.
[Abstract]

Article: Identification of ions in experimental electrostatic
potential maps

Journal: International Union of Crystallography Journal
Author: Jimin Wang, et al.
[Abstract]

Article: New Opportunities Created by Single-Particle Cryo-EM:
The Mapping of Conformational Space

Journal: Biochemistry
Author: Joachim Frank
[Preview]

Article: Channel opening and gating mechanism in AMPA-subtype
glutamate receptors

Journal: Nature
Authors: Edward C. Twomey, et al.
[Abstract]

Article: Structural Bases of Desensitization in AMPA Receptor-Auxiliary
Subunit Complexes

Journal: Neuron
Authors: Edward C. Twomey, et al.
[Abstract]

Article: A Fast and Effective Microfluidic Spraying-Plunging Method for High-Resolution Single-Particle Cryo-EM
Journal: Structure
Authors: Xiangsong Feng, et al.
[Abstract]

Article: Quantitative Characterization of Domain
Motions in Molecular Machines

Journal: The Journal of Physical Chemistry B
Authors: Suvrajit Maji, et al.
[Abstract]


Recent News


F1000Prime Faculty Member of the month
July 13, 2018

F1000Prime Blog: July’s faculty member of the month is Nobel laureate Joachim Frank. In 2017 he was awarded the Nobel Prize in Chemistry along with Richard Henderson and Jacques Dubochet for their pioneering work in cryogenic electron microscopy, a visualisation technique where a biological sample is cooled to extremely low temperatures of -150 °C. In this Q&A, we go back to October 2017 to talk about the day the Nobel prize winners were announced. Among the celebrating and the press engagements, Joachim still found the time to write...
Nobel lecture now online
Single-Particle Reconstruction of Biological Molecules---Story...

Featured in Physics World magazine
The rise and rise of cryogenic electron microscopy. Combining...

July 4th Tribute Honors 38 Distinguished Immigrants
Philanthropic foundation established by Scottish immigrant...