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Publications
Pallesen, J., Hashem, Y., Korkmaz, G., Koripella, R., Huang, C., Ehrenberg, M., Sanya, S., and Frank, J. (2013). Cryo-EM visualization of the ribosome in termination complex with apo-RF3 and RF1. eLife. PMID: 23755360; PMCid: PMC3677378.
Frank, J. (2013). Story in a Sample – the Potential (and Limitations) of Cryo-Electron Microscopy Applied to Molecular Machines. Biopolymers. PMID: 23640776; PMCid:
Hashem, Y., des Georges, A., Dhote, V., Langlois, R., Liao, H.L., Grassucci, R.A., Hellen, C.U.T., Pestova, T.V., and Frank, J. (2013b). Structure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29. Cell 153, 1108-1119. PMID: 23706745; PMCid:
Hashem, Y., des Georges, A., Fu, J., Buss, S.N., Jossinet, F., Jobe, A., Zhang, Q., Liao, H.Y., Grassucci, R.A., Bajaj, C., Westhof, E., Madison-Antenucci, S., and Frank, J. (2013). High-resolution cryo-electron microscopy structure of Trypanosoma brucei ribosome. Nature 494, 385-389. PMID: 23395961; PMCid: PMC3659406
Li, W., Atkinson, G.C., Thakor, N.S., Allas, U., Lu, C., Chan, K., Tenson, T., Schulten, K., Wilson, K.S., Hauryliuk, V., and Frank, J. (2013). Mechanism of tetracycline resistance by ribosomal protection protein Tet(O). Nature Communications 4. PMID: 23403578; PMCid: PMC3576927.
Sharma, G., Pallesen, J., Das, S., Grassucci, R., Langlois, R., Hampton, C.M., Kelly, D.F., des Georges, A., and Frank, J. (2013). Affinity grid-based cryo-EM of PKC binding to RACK1 on the ribosome. J Struct Biol 181, 190-194. PMID: 23228487; PMCid:
Taylor, D., Unbehaun, A., Li, W., Das, S., Lei, J., Liao, H., Grassucci, R.A., Pestova, T., and Frank, J. (2012). Cryo-EM structure of the mammalian eukaryotic release factor eRF1–eRF3-associated termination complex. Proc Natl Acad Sci U S A 109, 18413-18418. PMID: 23091004; PMCid: PMC3494903.
Bussiere, C., Hashem, Y., Arora, S., Frank, J., Johnson, A.W. (2012). Integrity of the P-site is probed during maturation of the 60S ribosomal subunit. J Cell Biol 197, 747-759. PMID: 22689654; PMCid: PMC3373404.
Agirrezabala, X., Liao, H., Schreiner, E., Fu, J., Ortiz-Meoz, R.F., Schulten, K., Green, R., and Frank, J. (2012). Structural characterization of mRNA-tRNA translocation intermediates. Proc Natl Acad Sci U S A 109, 6094-6099. PMID: 22467828 PMCid: PMC3340995.
Henderson, R., Sali, A., Baker, M.L., Carragher, B., Devkota, B., Downing, K.H., Egelman, E.H., Feng, Z., Frank, J., Grigorieff, N., Jiang, W., Ludtke, S.J., Medalia, O., Penczek, P.A., Rosenthal, P.B., Rossmann, M.G., Schmid, M.F., Schroder, G.F., Steven, A.C., Stokes, D.L., Westbrook, J.D., Wriggers, W., Yang, H., Young, J., Berman, H.M., Chiu, W., Kleywegt, G.J., and Lawson, C.L. (2012). Outcome of the First Electron Microscopy Validation Task Force Meeting. Structure 20, 206-214. PMID: 22325770; PMCid: PMC3328769.
Langlois, R., Pallesen, J., Frank, J. (2011). Reference-free particle selection enhanced with semi-supervised machine learning for cryo-electron microscopy. Journal of Structural Biology 175, 353-361. PMID: 21708269; PMCid: PMC3205936.
Langlois, R., Frank, J. (2011). A Clarification of the Terms Used in Comparing Semi-automated Particle Selection Algorithms in Cryo-EM. J Struct Biol 175, 348-352. PMID: 21420497; PMCid: PMC3164847.
Fu, J., Hashem, Y., Wower, J., and Frank, J. (2011). tmRNA on its way through the ribosome: Two steps of resume, and what next? RNA Biol 8, 586-590. PMID: 21593606; PMCid: PMC3225978.
Fu, J., Munro, J.B., Blanchard, S.C., Frank, J. (2011). Cryo-EM structures of the ribosome complex in intermediate states during tRNA translocation. Proc Natl Acad Sci U S A 108, 4817-4821. PMID: 21383139; PMCid: PMC3064370.
Agirrezabala, X., Schreiner, E., Trabuco, L.G., Lei, J., Ortiz-Meoz, R. F., Schulten, K., Green, R., and Frank, F. (2011). Structural insights into cognate vs. near-cognate discrimination during decoding. EMBO J 30, 1497-1507. PMID: 21378755; PMCid: PMC3102289.
Li, W., Trabuco, L.G., Schulten, K., Frank, F. (2011). Molecular dynamics of EF-G during translocation. Proteins 79, 1478-1486. PMID: 21365677; PMCid: PMC3132869.
Sengupta, J., Bussiere, C., Pallesen, J., West, M., Johnson, A., and Frank, J. (2010). Characterization of the nuclear export adaptor protein Nmd3 in association with the 60S ribosomal subunit. Journal of Cell Biology 7, 1079-1086. PMID: 20584915; PMCid: PMC2894450.
Reblova K, R.F., Li W, Gao H, Frank J, Sponer J (2010). Dynamics of the base of ribosomal A-site finger revealed by molecular dynamics simulations and Cryo-EM. Nucleic Acids Res 38, 1325-1340. PMID: 19952067; PMCid: PMC2831300.
Liao, H., and Frank, J. (2010). Classification by bootstrapping in single particle methods. Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro IEEE International Symposium on Biomedica 2010, 169-172. PMID: 20729994; NIHMS180400; PMCid: PMC2924593.
Huang T, S.T., Gupta K, Contreras-Martin LM, Grassucci RA, Van Duyne GD, Frank J, Belfort M. (2010). The group II intron ribonucleoprotein precursor is a large, loosely packed structure. Nucleic Acids Res 39, 2845-2854. PMID: 21131279; PMCid: PMC3074136.
Fu, J., Hashem, Y., Wower, I., Lei, J., Liao, H. Y., Zwieb, C., Wower, J., and Frank, J. (2010). Visualizing the transfer-messenger RNA as the ribosome resumes translation. EMBO J 29, 3819-3825. PMID: 20940705; PMCid: PMC2989109.
Villa, E., Sengupta, J., Trabuco, L.G., LeBarron, J., Baxter, W.T., Shaikh, T.R., Grassucci, R.A., Nissen, P., Ehrenberg, M., Schulten, K. (2009). Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis. Proc Natl Acad Sci U S A 106, 1063-1068. PMID: 19122150; PMCid: PMC2613361.
Taylor, D., Devkota, B., Huang, A.D., Topf, M., Narayanan, E., Sali, A., Harvey, S.C., and Frank, J. (2009). Comprehensive molecular structure of the eukaryotic ribosome. Structure 17, 1591-1604. PMID: 20004163; PMCid: 2814252.
Sorci, M., Grassucci, R.A., Hahn, I., Frank, J., and Belfort, G. (2009). Time-dependent insulin oligomer reaction pathway prior to fibril formation: cooling and seeding. Proteins 77, 62-73. PMID: 19408310; 130867; PMCid: PMC2737737.
Shi, Y., Giammartino, D. C. D., Taylor, D.J., Sarkeshik, A., Rice, W. J., Yates III, J.R., Frank, J., and Manley, J. L. (2009). Molecular architecture of the human pre-mRNA 3′ processing complex. Mol Cell 33, 365-376. PMID: NIHMS180078; PMCid: PMC2946185.
Fu, J., Kennedy, D., Munro, J., Lei, J., Blanchard, S., Frank, J. (2009). The P-site tRNA Reaches the P/E Position Through Intermediate Positions. Journal of Biomolecular Structure and Dynamics, Book of Abstracts: Albany 2009. PMID: PMCid:
Baxter, W.T., Grassucci, R.A., Gao, H., and Frank, J. (2009). Determination of signal-to-noise ratios and spectral SNRs in cryo-EM low-dose imaging of molecules. J Struct Biol 166, 126-132. PMID: 19269332; 112289 PMCid: PMC2700974.
Trabuco, L.G., Villa, E., Mitra, K., Frank, J., and Schulten, K. (2008). Flexible fitting of atomic structures into electron microscopy maps using molecular dynamics. Structure 16, 673-683. PMID: 18462672; PMCid: PMC2430731.
Shaikh, T.R., Trujillo, R., LeBarron, J.S., Baxter, W.T., and Frank, J. (2008). Particle-verification for single-particle, reference-based reconstruction using multivariate data analysis and classification. J Struct Biol 164, 41-48. PMID: 18619547; PMCid: PMC2577219.
Sengupta, J., Nilsson, J., Gursky, R., Kjeldgaard, M., Nissen, P., and Frank, J. (2008). Visualization of the eEF2-80S ribosome transition-state complex by cryo-electron microscopy. J Mol Biol 382, 179-187. PMID: 18644383; NIHMS69680; PMCid: PMC2990977.
Renken, C., Hsieh, C.E., Marko, M., Rath, B., Leith, A., Wagenknecht, T., Frank, J., and Mannella, C.A. (2008). Structure of frozen-hydrated triad junctions: A case study in motif searching inside tomograms. J Struct Biol 165, 53-63. PMID: 19028586; PMCid: PMC2655133.
Li, W., Agirrezabala, X., Lei, J., Bouakaz, L., Brunelle, J.L., Ortiz-Meoz, R.F., Green, R., Sanyal, S., Ehrenberg, M., and Frank, J. (2008). Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM. EMBO J 27, 3322-3331. PMID: 19020518; PMCid: PMC2586802.
LeBarron, J., Grassucci, R.A., Shaikh, T.R., Baxter, W.T., Sengupta, J., and Frank, J. (2008). Exploration of parameters in cryo-EM leading to an improved density map of the E. coli ribosome. J Struct Biol 164, 24-32. PMID: 18606549; PMCid: PMC2668984.
Agirrezabala, X., Lei, J., Brunelle, J.L., Ortiz-Meoz, R.F., Green, R., and Frank, J. (2008). Visualization of the hybrid state of tRNA binding promoted by spontaneous ratcheting of the ribosome. Mol Cell 32, 190-197. PMID: 18951087; PMCid: PMC2614368.
Yang, C., Penczek, P.A., Leith, A., Asturias, F.J., Ng, E.G., Glaeser, R.M., and Frank, J. (2007). The parallelization of SPIDER on distributed-memory computers using MPI. J Struct Biol 157, 240-249. PMID: 16859923; PMCid:
Taylor, D.J., Nilsson, J., Merrill, A.R., Andersen, G.R., Nissen, P., and Frank, J. (2007). Structures of modified eEF2 80S ribosome complexes reveal the role of GTP hydrolysis in translocation. EMBO J 26, 2421-2431. PMID: 17446867; PMCid: PMC1864975.
Scheres, S.H., Gao, H., Valle, M., Herman, G.T., Eggermont, P.P., Frank, J., and Carazo, J.M. (2007). Disentangling conformational states of macromolecules in 3D-EM through likelihood optimization. Nat Methods 4, 27-29. PMID: 17179934; PMCid:
Nilsson, J., Sengupta, J., Gursky, R., Nissen, P., and Frank, J. (2007). Comparison of fungal 80 S ribosomes by cryo-EM reveals diversity in structure and conformation of rRNA expansion segments. J Mol Biol 369, 429-438. PMID: 17434183; PMCid: PMC1976601.
Marko, M., Hsieh, C., Schalek, R., Frank, J., and Mannella, C. (2007). Focused-ion-beam thinning of frozen-hydrated biological specimens for cryo-electron microscopy. Nat Methods 4, 215-217. PMID: 17277781; PMCid:
Li, W., and Frank, J. (2007). Transfer RNA in the hybrid P/E state: correlating molecular dynamics simulations with cryo-EM data. Proc Natl Acad Sci U S A 104, 16540-16545. PMID: 17925437; PMCid: PMC2034235.
LeBarron, J., Mitra, K., and Frank, J. (2007). Displaying 3D data on RNA secondary structures: coloRNA. J Struct Biol 157, 262-270. PMID: 17070699; PMCid:
Gillet, R., Kaur, S., Li, W., Hallier, M., Felden, B., and Frank, J. (2007). Scaffolding as an organizing principle in trans-translation. The roles of small protein B and ribosomal protein S1. J Biol Chem 282, 6356-6363. PMID: 17179154; PMCid: PMC3230075
Gao, N., Zavialov, A.V., Ehrenberg, M., and Frank, J. (2007). Specific interaction between EF-G and RRF and its implication for GTP-dependent ribosome splitting into subunits. J Mol Biol 374, 1345-1358. PMID: 17996252; PMCid: PMC2211570.
Gao, H., Zhou, Z., Rawat, U., Huang, C., Bouakaz, L., Wang, C., Cheng, Z., Liu, Y., Zavialov, A., Gursky, R., Sanyal, S., Ehrenberg, M., Frank, J., and Song, H. (2007). RF3 induces ribosomal conformational changes responsible for dissociation of class I release factors. Cell 129, 929-941. PMID: 17540173; PMCid:
Fu, J., Gao, H., and Frank, J. (2007). Unsupervised classification of single particles by cluster tracking in multi-dimensional space. J Struct Biol 157, 226-239. PMID: 16931050; PMCid:
Frank, J., Gao, H., Sengupta, J., Gao, N., and Taylor, D.J. (2007). The process of mRNA-tRNA translocation. Proc Natl Acad Sci U S A 104, 19671-19678. PMID: 18003906; PMCid: PMC2148355.
Baxter, W.T., Leith, A., and Frank, J. (2007). SPIRE: the SPIDER reconstruction engine. J Struct Biol 157, 56-63. PMID: 17055743; PMCid:
Slagter-Jager, J.G., Allen, G.S., Smith, D., Hahn, I.A., Frank, J., and Belfort, M. (2006). Visualization of a group II intron in the 23S rRNA of a stable ribosome. Proc Natl Acad Sci U S A 103, 9838-9843. PMID: 16785426; PMCid: PMC1502540.
Rawat, U., Gao, H., Zavialov, A., Gursky, R., Ehrenberg, M., and Frank, J. (2006). Interactions of the release factor RF1 with the ribosome as revealed by cryo-EM. J Mol Biol 357, 1144-1153. PMID: 16476444; PMCid:
Penczek, P.A., Yang, C., Frank, J., and Spahn, C.M. (2006). Estimation of variance in single-particle reconstruction using the bootstrap technique. J Struct Biol 154, 168-183. PMID: 16510296; PMCid:
Penczek, P.A., Frank, J., and Spahn, C.M. (2006). A method of focused classification, based on the bootstrap 3D variance analysis, and its application to EF-G-dependent translocation. J Struct Biol 154, 184-194. PMID: 16520062; PMCid:
Mitra, K., Schaffitzel, C., Fabiola, F., Chapman, M.S., Ban, N., and Frank, J. (2006). Elongation arrest by SecM via a cascade of ribosomal RNA rearrangements. Mol Cell 22, 533-543. PMID: 16713583; PMCid:
Mitra, K., Frank, J., and Driessen, A. (2006). Co- and post-translational translocation through the protein-conducting channel: analogous mechanisms at work? Nat Struct Mol Biol 13, 957-964. PMID: 17082791; PMCid:
Mitra, K., and Frank, J. (2006). A model for co-translational translocation: ribosome-regulated nascent polypeptide translocation at the protein-conducting channel. FEBS Lett 580, 3353-3360. PMID: 16714018; PMCid:
Marko, M., Hsieh, C., Moberlychan, W., Mannella, C.A., and Frank, J. (2006). Focused ion beam milling of vitreous water: prospects for an alternative to cryo-ultramicrotomy of frozen-hydrated biological samples. J Microsc 222, 42-47. PMID: 16734713; PMCid:
Li, W., Sengupta, J., Rath, B.K., and Frank, J. (2006). Functional conformations of the L11-ribosomal RNA complex revealed by correlative analysis of cryo-EM and molecular dynamics simulations. RNA 12, 1240-1253. PMID: 16682558; PMCid: PMC1484425.
Kaur, S., Gillet, R., Li, W., Gursky, R., and Frank, J. (2006). Cryo-EM visualization of transfer messenger RNA with two SmpBs in a stalled ribosome. Proc Natl Acad Sci U S A 103, 16484-16489. PMID: 17056712; PMCid: PMC1618813.
Hsieh, C.E., Leith, A., Mannella, C.A., Frank, J., and Marko, M. (2006). Towards high-resolution three-dimensional imaging of native mammalian tissue: electron tomography of frozen-hydrated rat liver sections. J Struct Biol 153, 1-13. PMID: 16343943; PMCid:
Mitra, K., Schaffitzel, C., Shaikh, T., Tama, F., Jenni, S., Brooks, C.L., 3rd, Ban, N., and Frank, J. (2005). Structure of the E. coli protein-conducting channel bound to a translating ribosome. Nature 438, 318-324. PMID: 16292303; PMCid: 1351281.
Lei, J., and Frank, J. (2005). Automated acquisition of cryo-electron micrographs for single particle reconstruction on an FEI Tecnai electron microscope. J Struct Biol 150, 69-80. PMID: 15797731; PMCid:
Halic, M., Becker, T., Frank, J., Spahn, C.M., and Beckmann, R. (2005). Localization and dynamic behavior of ribosomal protein L30e. Nat Struct Mol Biol 12, 467-468. PMID: 15864315; PMCid:
Gao, N., Zavialov, A.V., Li, W., Sengupta, J., Valle, M., Gursky, R.P., Ehrenberg, M., and Frank, J. (2005). Mechanism for the disassembly of the posttermination complex inferred from cryo-EM studies. Mol Cell 18, 663-674. PMID: 15949441; PMCid:
Gao, H., and Frank, J. (2005). Molding atomic structures into intermediate-resolution cryo-EM density maps of ribosomal complexes using real-space refinement. Structure 13, 401-406. PMID: 15766541; PMCid:
Gao, H., Ayub, M.J., Levin, M.J., and Frank, J. (2005). The structure of the 80S ribosome from Trypanosoma cruzi reveals unique rRNA components. Proc Natl Acad Sci U S A 102, 10206-10211. PMID: 16014419; PMCid: PMC1174928.
Datta, P.P., Sharma, M.R., Qi, L., Frank, J., and Agrawal, R.K. (2005). Interaction of the G’ domain of elongation factor G and the C-terminal domain of ribosomal protein L7/L12 during translocation as revealed by cryo-EM. Mol Cell 20, 723-731. PMID: 16337596; PMCid:
Allen, G.S., Zavialov, A., Gursky, R., Ehrenberg, M., and Frank, J. (2005). The cryo-EM structure of a translation initiation complex from Escherichia coli. Cell 121, 703-712. PMID: 15935757; PMCid:
Adiga, U., Baxter, W.T., Hall, R.J., Rockel, B., Rath, B.K., Frank, J., and Glaeser, R. (2005). Particle picking by segmentation: a comparative study with SPIDER-based manual particle picking. J Struct Biol 152, 211-220. PMID: 16330229; PMCid:
Spahn, C.M., Jan, E., Mulder, A., Grassucci, R.A., Sarnow, P., and Frank, J. (2004). Cryo-EM visualization of a viral internal ribosome entry site bound to human ribosomes: the IRES functions as an RNA-based translation factor. Cell 118, 465-475. PMID: 15315759; PMCid:
Spahn, C.M., Gomez-Lorenzo, M.G., Grassucci, R.A., Jorgensen, R., Andersen, G.R., Beckmann, R., Penczek, P.A., Ballesta, J.P., and Frank, J. (2004). Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation. EMBO J 23, 1008-1019. PMID: 14976550; PMCid: 380967.
Sengupta, J., Nilsson, J., Gursky, R., Spahn, C.M., Nissen, P., and Frank, J. (2004). Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM. Nat Struct Mol Biol 11, 957-962. PMID: 15334071; PMCid:
Rath, B.K., and Frank, J. (2004). Fast automatic particle picking from cryo-electron micrographs using a locally normalized cross-correlation function: a case study. J Struct Biol 145, 84-90. PMID: 15065676; PMCid:
Nilsson, J., Sengupta, J., Frank, J., and Nissen, P. (2004). Regulation of eukaryotic translation by the RACK1 protein: a platform for signalling molecules on the ribosome. EMBO Rep 5, 1137-1141. PMID: 15577927; PMCid: 1299186.
Halic, M., Becker, T., Pool, M.R., Spahn, C.M., Grassucci, R.A., Frank, J., and Beckmann, R. (2004). Structure of the signal recognition particle interacting with the elongation-arrested ribosome. Nature 427, 808-814. PMID: 14985753; PMCid:
Gao, H., Valle, M., Ehrenberg, M., and Frank, J. (2004). Dynamics of EF-G interaction with the ribosome explored by classification of a heterogeneous cryo-EM dataset. J Struct Biol 147, 283-290. PMID: 15450297; PMCid:
Agrawal, R.K., Sharma, M.R., Kiel, M.C., Hirokawa, G., Booth, T.M., Spahn, C.M., Grassucci, R.A., Kaji, A., and Frank, J. (2004). Visualization of ribosome-recycling factor on the Escherichia coli 70S ribosome: functional implications. Proc Natl Acad Sci U S A 101, 8900-8905. PMID: 15178758; PMCid: 428444.
Yarus, M., Valle, M., and Frank, J. (2003). A twisted tRNA intermediate sets the threshold for decoding. RNA 9, 384-385. PMID: 12649490; PMCid: 1370405.
Valle, M., Zavialov, A., Sengupta, J., Rawat, U., Ehrenberg, M., and Frank, J. (2003). Locking and unlocking of ribosomal motions. Cell 114, 123-134. PMID: 12859903; PMCid:
Valle, M., Zavialov, A., Li, W., Stagg, S.M., Sengupta, J., Nielsen, R.C., Nissen, P., Harvey, S.C., Ehrenberg, M., and Frank, J. (2003). Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopy. Nat Struct Biol 10, 899-906. PMID: 14566331; PMCid:
Valle, M., Gillet, R., Kaur, S., Henne, A., Ramakrishnan, V., and Frank, J. (2003). Visualizing tmRNA entry into a stalled ribosome. Science 300, 127-130. PMID: 12677067; PMCid:
Tama, F., Valle, M., Frank, J., and Brooks, C.L., 3rd (2003). Dynamic reorganization of the functionally active ribosome explored by normal mode analysis and cryo-electron microscopy. Proc Natl Acad Sci U S A 100, 9319-9323. PMID: 12878726; PMCid: 170916.
Shaikh, T.R., Hegerl, R., and Frank, J. (2003). An approach to examining model dependence in EM reconstructions using cross-validation. J Struct Biol 142, 301-310. PMID: 12713958; PMCid:
Rawat, U.B., Zavialov, A.V., Sengupta, J., Valle, M., Grassucci, R.A., Linde, J., Vestergaard, B., Ehrenberg, M., and Frank, J. (2003). A cryo-electron microscopic study of ribosome-bound termination factor RF2. Nature 421, 87-90. PMID: 12511960; PMCid:
Rath, B.K., Hegerl, R., Leith, A., Shaikh, T.R., Wagenknecht, T., and Frank, J. (2003). Fast 3D motif search of EM density maps using a locally normalized cross-correlation function. J Struct Biol 144, 95-103. PMID: 14643212; PMCid:
Moccia, R., Chen, D., Lyles, V., Kapuya, E., E, Y., Kalachikov, S., Spahn, C.M., Frank, J., Kandel, E.R., Barad, M., and Martin, K.C. (2003). An unbiased cDNA library prepared from isolated Aplysia sensory neuron processes is enriched for cytoskeletal and translational mRNAs. J Neurosci 23, 9409-9417. PMID: 14561869; PMCid:
Gomez-Lorenzo, M.G., Valle, M., Frank, J., Gruss, C., Sorzano, C.O., Chen, X.S., Donate, L.E., and Carazo, J.M. (2003). Large T antigen on the simian virus 40 origin of replication: a 3D snapshot prior to DNA replication. EMBO J 22, 6205-6213. PMID: 14633980; PMCid: 291853.
Gao, H., Sengupta, J., Valle, M., Korostelev, A., Eswar, N., Stagg, S.M., Van Roey, P., Agrawal, R.K., Harvey, S.C., Sali, A., Chapman, M.S., and Frank, J. (2003). Study of the structural dynamics of the E coli 70S ribosome using real-space refinement. Cell 113, 789-801. PMID: 12809609; PMCid:
Valle, M., Sengupta, J., Swami, N.K., Grassucci, R.A., Burkhardt, N., Nierhaus, K.H., Agrawal, R.K., and Frank, J. (2002). Cryo-EM reveals an active role for aminoacyl-tRNA in the accommodation process. EMBO J 21, 3557-3567. PMID: 12093756; PMCid: 126079.
Stagg, S.M., Valle, M., Agrawal, R.K., Frank, J., and Harvey, S.C. (2002). Problems with the transorientation hypothesis. RNA 8, 1093-1094. PMID: 12358427; PMCid: 1370322.
Hsieh, C.E., Marko, M., Frank, J., and Mannella, C.A. (2002). Electron tomographic analysis of frozen-hydrated tissue sections. J Struct Biol 138, 63-73. PMID: 12160702; PMCid:
Gao, H., Spahn, C.M., Grassucci, R.A., and Frank, J. (2002). An assay for local quality in cryo-electron micrographs of single particles. Ultramicroscopy 93, 169-178. PMID: 12425594; PMCid:
Spahn, C.M., Kieft, J.S., Grassucci, R.A., Penczek, P.A., Zhou, K., Doudna, J.A., and Frank, J. (2001). Hepatitis C virus IRES RNA-induced changes in the conformation of the 40S ribosomal subunit. Science 291, 1959-1962. PMID: 11239155; PMCid:
Spahn, C.M., Blaha, G., Agrawal, R.K., Penczek, P., Grassucci, R.A., Trieber, C.A., Connell, S.R., Taylor, D.E., Nierhaus, K.H., and Frank, J. (2001). Localization of the ribosomal protection protein Tet(O) on the ribosome and the mechanism of tetracycline resistance. Mol Cell 7, 1037-1045. PMID: 11389850; PMCid:
Spahn, C.M., Beckmann, R., Eswar, N., Penczek, P.A., Sali, A., Blobel, G., and Frank, J. (2001). Structure of the 80S ribosome from Saccharomyces cerevisiae–tRNA-ribosome and subunit-subunit interactions. Cell 107, 373-386. PMID: 11701127; PMCid:
Sengupta, J., Agrawal, R.K., and Frank, J. (2001). Visualization of protein S1 within the 30S ribosomal subunit and its interaction with messenger RNA. Proc Natl Acad Sci U S A 98, 11991-11996. PMID: 11593008; PMCid: 59823.
McEwen, B.F., and Frank, J. (2001). Electron tomographic and other approaches for imaging molecular machines. Curr Opin Neurobiol 11, 594-600. PMID: 11595494; PMCid:
Gabashvili, I.S., Gregory, S.T., Valle, M., Grassucci, R., Worbs, M., Wahl, M.C., Dahlberg, A.E., and Frank, J. (2001). The polypeptide tunnel system in the ribosome and its gating in erythromycin resistance mutants of L4 and L22. Mol Cell 8, 181-188. PMID: 11511371; PMCid:
Beckmann, R., Spahn, C.M., Eswar, N., Helmers, J., Penczek, P.A., Sali, A., Frank, J., and Blobel, G. (2001). Architecture of the protein-conducting channel associated with the translating 80S ribosome. Cell 107, 361-372. PMID: 11701126; PMCid:
Agrawal, R.K., Linde, J., Sengupta, J., Nierhaus, K.H., and Frank, J. (2001). Localization of L11 protein on the ribosome and elucidation of its involvement in EF-G-dependent translocation. J Mol Biol 311, 777-787. PMID: 11518530; PMCid:
Wriggers, W., Agrawal, R.K., Drew, D.L., McCammon, A., and Frank, J. (2000). Domain motions of EF-G bound to the 70S ribosome: insights from a hand-shaking between multi-resolution structures. Biophys J 79, 1670-1678. PMID: 10969026; PMCid: 1301058.
VanLoock, M.S., Agrawal, R.K., Gabashvili, I.S., Qi, L., Frank, J., and Harvey, S.C. (2000). Movement of the decoding region of the 16 S ribosomal RNA accompanies tRNA translocation. J Mol Biol 304, 507-515. PMID: 11099376; PMCid:
Spahn, C.M., Penczek, P.A., Leith, A., and Frank, J. (2000). A method for differentiating proteins from nucleic acids in intermediate-resolution density maps: cryo-electron microscopy defines the quaternary structure of the Escherichia coli 70S ribosome. Structure 8, 937-948. PMID: 10986461; PMCid:
Gomez-Lorenzo, M.G., Spahn, C.M., Agrawal, R.K., Grassucci, R.A., Penczek, P., Chakraburtty, K., Ballesta, J.P., Lavandera, J.L., Garcia-Bustos, J.F., and Frank, J. (2000). Three-dimensional cryo-electron microscopy localization of EF2 in the Saccharomyces cerevisiae 80S ribosome at 17.5 Å resolution. EMBO J 19, 2710-2718. PMID: 10835368; PMCid: 212750.
Gabashvili, I.S., Agrawal, R.K., Spahn, C.M., Grassucci, R.A., Svergun, D.I., Frank, J., and Penczek, P. (2000). Solution structure of the E. coli 70S ribosome at 11.5 Å resolution. Cell 100, 537-549. PMID: 10721991; PMCid:
Frank, J., and Agrawal, R.K. (2000). A ratchet-like inter-subunit reorganization of the ribosome during translocation. Nature 406, 318-322. PMID: 10917535; PMCid:
Agrawal, R.K., Spahn, C.M., Penczek, P., Grassucci, R.A., Nierhaus, K.H., and Frank, J. (2000). Visualization of tRNA movements on the Escherichia coli 70S ribosome during the elongation cycle. J Cell Biol 150, 447-460. PMID: 10931859; PMCid: 2175196.
Spahn, C.M., Grassucci, R.A., Penczek, P., and Frank, J. (1999). Direct three-dimensional localization and positive identification of RNA helices within the ribosome by means of genetic tagging and cryo-electron microscopy. Structure 7, 1567-1573. PMID: 10647187; PMCid:
McCutcheon, J.P., Agrawal, R.K., Philips, S.M., Grassucci, R.A., Gerchman, S.E., Clemons, W.M., Jr., Ramakrishnan, V., and Frank, J. (1999). Location of translational initiation factor IF3 on the small ribosomal subunit. Proc Natl Acad Sci U S A 96, 4301-4306. PMID: 10200257; PMCid: PMC16327
Gabashvili, I.S., Agrawal, R.K., Grassucci, R., Squires, C.L., Dahlberg, A.E., and Frank, J. (1999). Major rearrangements in the 70S ribosomal 3D structure caused by a conformational switch in 16S ribosomal RNA. EMBO J 18, 6501-6507. PMID: 10562562; PMCid:
Gabashvili, I.S., Agrawal, R.K., Grassucci, R., and Frank, J. (1999). Structure and structural variations of the Escherichia coli 30 S ribosomal subunit as revealed by three-dimensional cryo-electron microscopy. J Mol Biol 286, 1285-1291. PMID: 10064696; PMCid:
Frank, J., Heagle, A.B., and Agrawal, R.K. (1999). Animation of the dynamical events of the elongation cycle based on cryoelectron microscopy of functional complexes of the ribosome. J Struct Biol 128, 15-18. PMID: 10600553; PMCid:
Agrawal, R.K., Penczek, P., Grassucci, R.A., Burkhardt, N., Nierhaus, K.H., and Frank, J. (1999). Effect of buffer conditions on the position of tRNA on the 70 S ribosome as visualized by cryoelectron microscopy. J Biol Chem 274, 8723-8729. PMID: 10085112; PMCid:
Agrawal, R.K., Heagle, A.B., Penczek, P., Grassucci, R.A., and Frank, J. (1999). EF-G-dependent GTP hydrolysis induces translocation accompanied by large conformational changes in the 70S ribosome. Nat Struct Biol 6, 643-647. PMID: 10404220; PMCid:
Verschoor, A., Warner, J.R., Srivastava, S., Grassucci, R.A., and Frank, J. (1998). Three-dimensional structure of the yeast ribosome. Nucleic Acids Res 26, 655-661. PMID: 9421530; PMCid:
Samso, M., Radermacher, M., Frank, J., and Koonce, M.P. (1998). Structural characterization of a dynein motor domain. J Mol Biol 276, 927-937. PMID: 9566197; PMCid:
Malhotra, A., Penczek, P., Agrawal, R.K., Gabashvili, I.S., Grassucci, R.A., Junemann, R., Burkhardt, N., Nierhaus, K.H., and Frank, J. (1998). Escherichia coli 70 S ribosome at 15 Å resolution by cryo-electron microscopy: localization of fMet-tRNAfMet and fitting of L1 protein. J Mol Biol 280, 103-116. PMID: 9653034; PMCid:
Frank, J., and Agrawal, R.K. (1998). The movement of tRNA through the ribosome. Biophys J 74, 589-594. PMID: 9449359; PMCid:
Ban, N., Freeborn, B., Nissen, P., Penczek, P., Grassucci, R.A., Sweet, R., Frank, J., Moore, P.B., and Steitz, T.A. (1998). A 9 Å resolution X-ray crystallographic map of the large ribosomal subunit. Cell 93, 1105-1115. PMID: 9657144; PMCid:
Agrawal, R.K., Penczek, P., Grassucci, R.A., and Frank, J. (1998). Visualization of elongation factor G on the Escherichia coli 70S ribosome: the mechanism of translocation. Proc Natl Acad Sci U S A 95, 6134-6138. PMID: 9600930; PMCid:
Zhu, J., Penczek, P.A., Schroder, R., and Frank, J. (1997). Three-dimensional reconstruction with contrast transfer function correction from energy-filtered cryoelectron micrographs: procedure and application to the 70S Escherichia coli ribosome. J Struct Biol 118, 197-219. PMID: 9169230; PMCid:
Wadzack, J., Burkhardt, N., Junemann, R., Diedrich, G., Nierhaus, K.H., Frank, J., Penczek, P., Meerwinck, W., Schmitt, M., Willumeit, R., and Stuhrmann, H.B. (1997). Direct localization of the tRNAs within the elongating ribosome by means of neutron scattering (proton-spin contrast-variation). J Mol Biol 266, 343-356. PMID: 9047368; PMCid:
Rath, B.K., Marko, M., Radermacher, M., and Frank, J. (1997). Low-dose automated electron tomography: a recent implementation. J Struct Biol 120, 210-218. PMID: 9441926; PMCid:
Li, Y., Leith, A., and Frank, J. (1997). Tinkerbell–a tool for interactive segmentation of 3D data. J Struct Biol 120, 266-275. PMID: 9441932; PMCid:
Beckmann, R., Bubeck, D., Grassucci, R., Penczek, P., Verschoor, A., Blobel, G., and Frank, J. (1997). Alignment of conduits for the nascent polypeptide chain in the ribosome-Sec61 complex. Science 278, 2123-2126. PMID: 9405348; PMCid:
Verschoor, A., Srivastava, S., Grassucci, R., and Frank, J. (1996). Native 3D structure of eukaryotic 80s ribosome: morphological homology with E. coli 70S ribosome. J Cell Biol 133, 495-505. PMID: 8636226; PMCid:
Penczek, P.A., Zhu, J., and Frank, J. (1996). A common-lines based method for determining orientations for N > 3 particle projections simultaneously. Ultramicroscopy 63, 205-218. PMID: 8921628; PMCid:
Marabini, R., Vaquerizo, C., Fernandez, J.J., Carazo, J.M., Engel, A., and Frank, J. (1996). Proposal for a new distributed database of macromolecular and subcellular structures from different areas of microscopy. J Struct Biol 116, 161-165. PMID: 8742739; PMCid:
Lata, K.R., Agrawal, R.K., Penczek, P., Grassucci, R., Zhu, J., and Frank, J. (1996). Three-dimensional reconstruction of the Escherichia coli 30 S ribosomal subunit in ice. J Mol Biol 262, 43-52. PMID: 8809178; PMCid:
Frank, J., Radermacher, M., Penczek, P., Zhu, J., Li, Y., Ladjadj, M., and Leith, A. (1996). SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields. J Struct Biol 116, 190-199. PMID: 8742743; PMCid:
Agrawal, R.K., Penczek, P., Grassucci, R.A., Li, Y., Leith, A., Nierhaus, K.H., and Frank, J. (1996). Direct visualization of A-, P-, and E-site transfer RNAs in the Escherichia coli ribosome. Science 271, 1000-1002. PMID: 8584922; PMCid:
Srivastava, S., Verschoor, A., Radermacher, M., Grassucci, R., and Frank, J. (1995). Three-dimensional reconstruction of mammalian 40 S ribosomal subunit embedded in ice. J Mol Biol 245, 461-466. PMID: 7844819; PMCid:
Penczek, P., Marko, M., Buttle, K., and Frank, J. (1995). Double-tilt electron tomography. Ultramicroscopy 60, 393-410. PMID: 8525550; PMCid:
Liu, Y., Penczek, P.A., McEwen, B.F., and Frank, J. (1995). A marker-free alignment method for electron tomography. Ultramicroscopy 58, 393-402. PMID: 7571119; PMCid:
Liu, W., and Frank, J. (1995). Estimation of variance distribution in three-dimensional reconstruction. I. Theory. J Opt Soc Am A Opt Image Sci Vis 12, 2615-2627. PMID: 7500221; PMCid:
Liu, W., Boisset, N., and Frank, J. (1995). Estimation of variance distribution in three-dimensional reconstruction. II. Applications. J Opt Soc Am A Opt Image Sci Vis 12, 2628-2635. PMID: 7500222; PMCid:
Lata, K.R., Penczek, P., and Frank, J. (1995). Automatic particle picking from electron micrographs. Ultramicroscopy 58, 381-391. PMID: 7571118; PMCid:
Frank, J., Zhu, J., Penczek, P., Li, Y., Srivastava, S., Verschoor, A., Radermacher, M., Grassucci, R., Lata, R.K., and Agrawal, R.K. (1995). A model of protein synthesis based on cryo-electron microscopy of the E. coli ribosome. Nature 376, 441-444. PMID: 7630422; PMCid:
Frank, J., and Penczek, P. (1995). On the correction of the contrast transfer function in biological electron microscopy. Optik 98, 125-129. PMID: PMCid:
Boisset, N., Penczek, P., Taveau, J.C., Lamy, J., and Frank, J. (1995). Three-dimensional reconstruction of Androctonus australis hemocyanin labeled with a monoclonal Fab fragment. J Struct Biol 115, 16-29. PMID: 7577229; PMCid:
Radermacher, M., Rao, V., Grassucci, R., Frank, J., Timerman, A.P., Fleischer, S., and Wagenknecht, T. (1994). Cryo-electron microscopy and three-dimensional reconstruction of the calcium release channel/ryanodine receptor from skeletal muscle. J Cell Biol 127, 411-423. PMID: 7929585; PMCid:
Penczek, P.A., Grassucci, R.A., and Frank, J. (1994). The ribosome at improved resolution: new techniques for merging and orientation refinement in 3D cryo-electron microscopy of biological particles. Ultramicroscopy 53, 251-270. PMID: 8160308; PMCid:
Mannella, C.A., Marko, M., Penczek, P., Barnard, D., and Frank, J. (1994). The internal compartmentation of rat-liver mitochondria: tomographic study using the high-voltage transmission electron microscope. Microsc Res Tech 27, 278-283. PMID: 8186446; PMCid:
Lambert, O., Boisset, N., Penczek, P., Lamy, J., Taveau, J.C., Frank, J., and Lamy, J.N. (1994). Quaternary structure of Octopus vulgaris hemocyanin. Three-dimensional reconstruction from frozen-hydrated specimens and intramolecular location of functional units Ove and Ovb. J Mol Biol 238, 75-87. PMID: 8145258; PMCid:
Boisset, N., Penczek, P., Pochon, F., Frank, J., and Lamy, J. (1994). Three-dimensional reconstruction of human alpha 2-macroglobulin and refinement of the localization of thiol ester bonds with monomaleimido nanogold. Ann N Y Acad Sci 737, 229-244. PMID: 7524399; PMCid:
McEwen, B.F., Arena, J.T., Frank, J., and Rieder, C.L. (1993). Structure of the colcemid-treated PtK1 kinetochore outer plate as determined by high voltage electron microscopic tomography. J Cell Biol 120, 301-312. PMID: 8421050; PMCid:
Frank, J., Chiu, W., and Henderson, R. (1993). Flopping polypeptide chains and Suleika’s subtle imperfections: analysis of variations in the electron micrograph of a purple membrane crystal. Ultramicroscopy 49, 387-396. PMID: 8475603; PMCid:
Boisset, N., Radermacher, M., Grassucci, R., Taveau, J.C., Liu, W., Lamy, J., Frank, J., and Lamy, J.N. (1993). Three-dimensional immunoelectron microscopy of scorpion hemocyanin labeled with a monoclonal Fab fragment. J Struct Biol 111, 234-244. PMID: 8003384; PMCid:
Boisset, N., Penczek, P., Pochon, F., Frank, J., and Lamy, J. (1993). Three-dimensional architecture of human alpha 2-macroglobulin transformed with methylamine. J Mol Biol 232, 522-529. PMID: 7688427; PMCid:
Wilson, C.J., Mastronarde, D.N., McEwen, B., and Frank, J. (1992). Measurement of neuronal surface area using high-voltage electron microscope tomography. Neuroimage 1, 11-22. PMID: 9343554; PMCid:
Srivastava, S., Verschoor, A., and Frank, J. (1992). Eukaryotic initiation factor 3 does not prevent association through physical blockage of the ribosomal subunit-subunit interface. J Mol Biol 226, 301-304. PMID: 1640449; PMCid:
Radermacher, M., Wagenknecht, T., Grassucci, R., Frank, J., Inui, M., Chadwick, C., and Fleischer, S. (1992). Cryo-EM of the native structure of the calcium release channel/ryanodine receptor from sarcoplasmic reticulum. Biophys J 61, 936-940. PMID: 1316182; PMCid:
Penczek, P., Radermacher, M., and Frank, J. (1992). Three-dimensional reconstruction of single particles embedded in ice. Ultramicroscopy 40, 33-53. PMID: 1580010; PMCid:
Morgan, D.G., Grant, R.A., Chiu, W., and Frank, J. (1992). Patch averaging of electron images of GP3*I crystals with variable thickness. J Struct Biol 108, 245-256. PMID: 1335748; PMCid:
Frank, J., and Radermacher, M. (1992). Three-dimensional reconstruction of single particles negatively stained or in vitreous ice. Ultramicroscopy 46, 241-262. PMID: 1336233; PMCid:
Boisset, N., Grassucci, R., Penczek, P., Delain, E., Pochon, F., Frank, J., and Lamy, J.N. (1992). Three-dimensional reconstruction of a complex of human alpha 2-macroglobulin with monomaleimido Nanogold (Au1.4nm) embedded in ice. J Struct Biol 109, 39-45. PMID: 1283687; PMCid:
Barnard, D.P., Turner, J.N., Frank, J., and McEwen, B.F. (1992). A 360 degrees single-axis tilt stage for the high-voltage electron microscope. J Microsc 167, 39-48. PMID: 1527794; PMCid:
Woodcock, C.L., McEwen, B.F., and Frank, J. (1991). Ultrastructure of chromatin. II. Three-dimensional reconstruction of isolated fibers. J Cell Sci 99 ( Pt 1), 107-114. PMID: 1757495; PMCid:
Frank, J., Penczek, P., Grassucci, R., and Srivastava, S. (1991). Three-dimensional reconstruction of the 70S Escherichia coli ribosome in ice: the distribution of ribosomal RNA. J Cell Biol 115, 597-605. PMID: 1918155; PMCid:
Verschoor, A., and Frank, J. (1990). Three-dimensional structure of the mammalian cytoplasmic ribosome. J Mol Biol 214, 737-749. PMID: 2388265; PMCid:
Carazo, J.M., Rivera, F.F., Zapata, E.L., Radermacher, M., and Frank, J. (1990). Fuzzy sets-based classification of electron microscopy images of biological macromolecules with an application to ribosomal particles. J Microsc 157, 187-203. PMID: 2179560; PMCid:
Boisset, N., Taveau, J.C., Lamy, J., Wagenknecht, T., Radermacher, M., and Frank, J. (1990). Three-dimensional reconstruction of native Androctonus australis hemocyanin. J Mol Biol 216, 743-760. PMID: 2258938; PMCid:
Wagenknecht, T., Grassucci, R., Frank, J., Saito, A., Inui, M., and Fleischer, S. (1989). Three-dimensional architecture of the calcium channel/foot structure of sarcoplasmic reticulum. Nature 338, 167-170. PMID: 2537473; PMCid:
Wagenknecht, T., Carazo, J.M., Radermacher, M., and Frank, J. (1989). Three-dimensional reconstruction of the ribosome from Escherichia coli. Biophys J 55, 455-464. PMID: 2649163; PMCid:
Verschoor, A., Zhang, N.Y., Wagenknecht, T., Obrig, T., Radermacher, M., and Frank, J. (1989). Three-dimensional reconstruction of mammalian 40 S ribosomal subunit. J Mol Biol 209, 115-126. PMID: 2810364; PMCid:
Unser, M., Trus, B.L., Frank, J., and Steven, A.C. (1989). The spectral signal-to-noise ratio resolution criterion: computational efficiency and statistical precision. Ultramicroscopy 30, 429-433. PMID: 2800044; PMCid:
Carazo, J.M., Wagenknecht, T., and Frank, J. (1989). Variations of the three-dimensional structure of the Escherichia coli ribosome in the range of overlap views. An application of the methods of multicone and local single-cone three-dimensional reconstruction. Biophys J 55, 465-477. PMID: 2649164; PMCid:
Wagenknecht, T., Grassucci, R., and Frank, J. (1988). Electron microscopy and computer image averaging of ice-embedded large ribosomal subunits from Escherichia coli. J Mol Biol 199, 137-147. PMID: 2451023; PMCid:
Wagenknecht, T., Frank, J., Boublik, M., Nurse, K., and Ofengand, J. (1988). Direct localization of the tRNA–anticodon interaction site on the Escherichia coli 30 S ribosomal subunit by electron microscopy and computerized image averaging. J Mol Biol 203, 753-760. PMID: 3062179; PMCid:
Saito, A., Inui, M., Radermacher, M., Frank, J., and Fleischer, S. (1988). Ultrastructure of the calcium release channel of sarcoplasmic reticulum. J Cell Biol 107, 211-219. PMID: 2455723; PMCid:
Frank, J., Chiu, W., and Degn, L. (1988). The characterization of structural variations within a crystal field. Ultramicroscopy 26, 345-360. PMID: 3238812; PMCid:
Frank, J., Bretaudiere, J.P., Carazo, J.M., Verschoor, A., and Wagenknecht, T. (1988). Classification of images of biomolecular assemblies: a study of ribosomes and ribosomal subunits of Escherichia coli. J Microsc 150, 99-115. PMID: 3045323; PMCid:
Carazo, J.M., Wagenknecht, T., Radermacher, M., Mandiyan, V., Boublik, M., and Frank, J. (1988). Three-dimensional structure of 50 S Escherichia coli ribosomal subunits depleted of proteins L7/L12. J Mol Biol 201, 393-404. PMID: 3047401; PMCid:
Carazo, J.M., and Frank, J. (1988). Three-dimensional matching of macromolecular structures obtained from electron microscopy: an application to the 70S and 50S E. coli ribosomal particles. Ultramicroscopy 25, 13-22. PMID: 3291355; PMCid:
Boisset, N., Frank, J., Taveau, J.C., Billiald, P., Motta, G., Lamy, J., and Sizaret, P.Y. (1988). Intramolecular localization of epitopes within an oligomeric protein by immunoelectron microscopy and image processing. Proteins 3, 161-183. PMID: 2474818; PMCid:
Radermacher, M., Wagenknecht, T., Verschoor, A., and Frank, J. (1987). Three-dimensional structure of the large ribosomal subunit from Escherichia coli. EMBO J 6, 1107-1114. PMID: 3297672; PMCid:
Radermacher, M., Wagenknecht, T., Verschoor, A., and Frank, J. (1987). Three-dimensional reconstruction from a single-exposure, random conical tilt series applied to the 50S ribosomal subunit of Escherichia coli. J Microsc 146, 113-136. PMID: 3302267; PMCid:
Mannella, C.A., Ribeiro, A.J., and Frank, J. (1987). Cytochrome c binds to lipid domains in arrays of mitochondrial outer membrane channels. Biophys J 51, 221-226. PMID: 3030457; PMCid:
Mannella, C.A., Frank, J., and Delihas, N. (1987). Interrelatedness of 5S RNA sequences investigated by correspondence analysis. J Mol Evol 24, 228-235. PMID: 3106638; PMCid:
Verschoor, A., Frank, J., Wagenknecht, T., and Boublik, M. (1986). Computer-averaged views of the 70 S monosome from Escherichia coli. J Mol Biol 187, 581-590. PMID: 3519978; PMCid:
Tsuji, M., Frank, J., and Manley, R.S.J. (1986). Image analysis in the electron microscopy of cellulose protofibrils. II: Digital correlation methods. Colloid and Polymer Science 264, 89-96. PMID: PMCid:
Radermacher, M., Wagenknecht, T., Verschoor, A., and Frank, J. (1986). A new 3-D reconstruction scheme applied to the 50S ribosomal subunit of E. coli. J Microsc 141, RP1-2. PMID: 3514918; PMCid:
McEwen, B.F., Radermacher, M., Rieder, C.L., and Frank, J. (1986). Tomographic three-dimensional reconstruction of cilia ultrastructure from thick sections. Proc Natl Acad Sci U S A 83, 9040-9044. PMID: 3466176; PMCid:
Mannella, C.A., Ribeiro, A., and Frank, J. (1986). Structure of the channels in the outer mitochondrial membrane: Electron microscopic studies of the periodic arrays induced by phospholipase A2 treatment of the Neurospora membrane. Biophysical Journal 49, 307-317. PMID: PMCid:
Mannella, C.A., and Frank, J. (1986). Effect of succinylation on images of negatively stained arrays of mitochondrial outer membrane channels. J Ultrastruct Mol Struct Res 96, 31-40. PMID: 2445865; PMCid:
Bretaudiere, J.P., and Frank, J. (1986). Reconstitution of molecule images analysed by correspondence analysis: a tool for structural interpretation. J Microsc 144, 1-14. PMID: 3632765; PMCid:
Verschoor, A., Frank, J., and Boublik, M. (1985). Investigation of the 50 S ribosomal subunit by electron microscopy and image analysis. J Ultrastruct Res 92, 180-189. PMID: 3913778; PMCid:
Subirana, J.A., Munoz-Guerra, S., Aymami, J., Radermacher, M., and Frank, J. (1985). The layered organization of nucleosomes in 30 nm chromatin fibers. Chromosoma 91, 377-390. PMID: 4039646; PMCid:
Radermacher, M., and Frank, J. (1985). Use of nonlinear mapping in multivariate image analysis of molecule projections. Ultramicroscopy 17, 117-126. PMID: 4071832; PMCid:
Parsons, D.F., Marko, M., Radermacher, M., and Frank, J. (1985). Shape changes and polarization of cells migrating through tissue. A high-voltage electron microscope and computer graphics study of serial thick sections. Tissue Cell 17, 491-510. PMID: 4049363; PMCid:
Lamy, J., Billiald, P., Sizaret, P.Y., Cave, G., Frank, J., and Motta, G. (1985). Approach to the direct intramolecular localization of antigenic determinants in Androctonus australis hemocyanin with monoclonal antibodies by molecular immunoelectron microscopy. Biochemistry 24, 5532-5542. PMID: 2416343; PMCid:
Kim, C.H., Radermacher, M., Kessel, M., Frank, J., and King, T.E. (1985). Three-dimensional reconstruction of cytochrome oxidase vesicle crystals prepared by cholate solubilization. J Inorg Biochem 23, 163-169. PMID: 2991453; PMCid:
Kessel, M., Radermacher, M., and Frank, J. (1985). The structure of the stalk surface layer of a brine pond microorganism: correlation averaging applied to a double layered lattice structure. J Microsc 139, 63-74. PMID: 4046014; PMCid:
Hui, S.W., and Frank, J. (1985). Analysis of the irregular planar distribution of proteins in membranes. J Microsc 137, 293-303. PMID: 3999133; PMCid:
Woodcock, C.L., and Frank, J. (1984). Nucleosome mass distribution using image averaging. J Ultrastruct Res 89, 295-302. PMID: 6544891; PMCid:
Wagenknecht, T., and Frank, J. (1984). Localization of lipoyl-bearing domains in the alpha-ketoglutarate dehydrogenase multienzyme complex. Biochemistry 23, 3383-3389. PMID: 6380587; PMCid:
Verschoor, A., Frank, J., Radermacher, M., Wagenknecht, T., and Boublik, M. (1984). Three-dimensional reconstruction of the 30 S ribosomal subunit from randomly oriented particles. J Mol Biol 178, 677-698. PMID: 6387155; PMCid:
Radermacher, M., and Frank, J. (1984). Representation of three-dimensionally reconstructed objects in electron microscopy by surfaces of equal density. J Microsc 136, 77-85. PMID: 6392559; PMCid:
Mannella, C.A., and Frank, J. (1984). Electron microscopic stains as probes of the surface charge of mitochondrial outer membrane channels. Biophysical Journal 45, 139-141. PMID: PMCid:
Haenicke, W., Frank, J., and Zingsheim, H.P. (1984). Statistical significance of molecule projections by single particle averaging. J Microsc 133, 223-238. PMID: 6708102; PMCid:
Frank, J., and Wagenknecht, T. (1984). Automatic selection of molecular images from electron micrographs. Ultramicroscopy 12, 169–176. PMID: PMCid:
Mannella, C.A., Colombini, M., and Frank, J. (1983). Structural and functional evidence for multiple channel complexes in the outer membrane of Neurospora crassa mitochondria. Proc Natl Acad Sci U S A 80, 2243-2247. PMID: 6300902; PMCid:
Zingsheim, H.P., Neugebauer, D.C., Frank, J., Hanicke, W., and Barrantes, F.J. (1982). Dimeric arrangement and structure of the membrane-bound acetylcholine receptor studied by electron microscopy. EMBO J 1, 541-547. PMID: 7188351; PMCid:
Zingsheim, H.P., Barrantes, F.J., Frank, J., Hanicke, W., and Neugebauer, D.C. (1982). Direct structural localization of two toxin-recognition sites on an ACh receptor protein. Nature 299, 81-84. PMID: 7110329; PMCid:
Sizaret, P.Y., Frank, J., Lamy, J., Weill, J., and Lamy, J.N. (1982). A refined quaternary structure of Androctonus australis Hemocyanin. Eur J Biochem 127, 501-506. PMID: 7173191; PMCid:
Mannella, C., and Frank, J. (1982). Effects of divalent metal ions and chelators on the structure of the outer mitochondrial membranes from Neurospora crassa. Biophysical Journal 37, 3-4. PMID: PMCid:
Lamy, J., Sizaret, P.Y., Frank, J., Verschoor, A., Feldmann, R., and Bonaventura, J. (1982). Architecture of Limulus polyphemus hemocyanin. Biochemistry 21, 6825-6833. PMID: 7159564; PMCid:
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Li, Y., Leith, A., and Frank, J. (1997). Tinkerbell–a tool for interactive segmentation of 3D data. J Struct Biol 120, 266-275. PMID: 9441932; PMCid:
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Wilson, C.J., Mastronarde, D.N., McEwen, B., and Frank, J. (1992). Measurement of neuronal surface area using high-voltage electron microscope tomography. Neuroimage 1, 11-22. PMID: 9343554; PMCid:
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Unser, M., Trus, B.L., Frank, J., and Steven, A.C. (1989). The spectral signal-to-noise ratio resolution criterion: computational efficiency and statistical precision. Ultramicroscopy 30, 429-433. PMID: 2800044; PMCid:
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Mannella, C.A., Ribeiro, A.J., and Frank, J. (1987). Cytochrome c binds to lipid domains in arrays of mitochondrial outer membrane channels. Biophys J 51, 221-226. PMID: 3030457; PMCid:
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Tsuji, M., Frank, J., and Manley, R.S.J. (1986). Image analysis in the electron microscopy of cellulose protofibrils. II: Digital correlation methods. Colloid and Polymer Science 264, 89-96. PMID: PMCid:
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McEwen, B.F., Radermacher, M., Rieder, C.L., and Frank, J. (1986). Tomographic three-dimensional reconstruction of cilia ultrastructure from thick sections. Proc Natl Acad Sci U S A 83, 9040-9044. PMID: 3466176; PMCid:
Mannella, C.A., Ribeiro, A., and Frank, J. (1986). Structure of the channels in the outer mitochondrial membrane: Electron microscopic studies of the periodic arrays induced by phospholipase A2 treatment of the Neurospora membrane. Biophysical Journal 49, 307-317. PMID: PMCid:
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Bretaudiere, J.P., and Frank, J. (1986). Reconstitution of molecule images analysed by correspondence analysis: a tool for structural interpretation. J Microsc 144, 1-14. PMID: 3632765; PMCid:
Verschoor, A., Frank, J., and Boublik, M. (1985). Investigation of the 50 S ribosomal subunit by electron microscopy and image analysis. J Ultrastruct Res 92, 180-189. PMID: 3913778; PMCid:
Subirana, J.A., Munoz-Guerra, S., Aymami, J., Radermacher, M., and Frank, J. (1985). The layered organization of nucleosomes in 30 nm chromatin fibers. Chromosoma 91, 377-390. PMID: 4039646; PMCid:
Radermacher, M., and Frank, J. (1985). Use of nonlinear mapping in multivariate image analysis of molecule projections. Ultramicroscopy 17, 117-126. PMID: 4071832; PMCid:
Parsons, D.F., Marko, M., Radermacher, M., and Frank, J. (1985). Shape changes and polarization of cells migrating through tissue. A high-voltage electron microscope and computer graphics study of serial thick sections. Tissue Cell 17, 491-510. PMID: 4049363; PMCid:
Lamy, J., Billiald, P., Sizaret, P.Y., Cave, G., Frank, J., and Motta, G. (1985). Approach to the direct intramolecular localization of antigenic determinants in Androctonus australis hemocyanin with monoclonal antibodies by molecular immunoelectron microscopy. Biochemistry 24, 5532-5542. PMID: 2416343; PMCid:
Kim, C.H., Radermacher, M., Kessel, M., Frank, J., and King, T.E. (1985). Three-dimensional reconstruction of cytochrome oxidase vesicle crystals prepared by cholate solubilization. J Inorg Biochem 23, 163-169. PMID: 2991453; PMCid:
Kessel, M., Radermacher, M., and Frank, J. (1985). The structure of the stalk surface layer of a brine pond microorganism: correlation averaging applied to a double layered lattice structure. J Microsc 139, 63-74. PMID: 4046014; PMCid:
Hui, S.W., and Frank, J. (1985). Analysis of the irregular planar distribution of proteins in membranes. J Microsc 137, 293-303. PMID: 3999133; PMCid:
Woodcock, C.L., and Frank, J. (1984). Nucleosome mass distribution using image averaging. J Ultrastruct Res 89, 295-302. PMID: 6544891; PMCid:
Wagenknecht, T., and Frank, J. (1984). Localization of lipoyl-bearing domains in the alpha-ketoglutarate dehydrogenase multienzyme complex. Biochemistry 23, 3383-3389. PMID: 6380587; PMCid:
Verschoor, A., Frank, J., Radermacher, M., Wagenknecht, T., and Boublik, M. (1984). Three-dimensional reconstruction of the 30 S ribosomal subunit from randomly oriented particles. J Mol Biol 178, 677-698. PMID: 6387155; PMCid:
Radermacher, M., and Frank, J. (1984). Representation of three-dimensionally reconstructed objects in electron microscopy by surfaces of equal density. J Microsc 136, 77-85. PMID: 6392559; PMCid:
Mannella, C.A., and Frank, J. (1984). Electron microscopic stains as probes of the surface charge of mitochondrial outer membrane channels. Biophysical Journal 45, 139-141. PMID: PMCid:
Haenicke, W., Frank, J., and Zingsheim, H.P. (1984). Statistical significance of molecule projections by single particle averaging. J Microsc 133, 223-238. PMID: 6708102; PMCid:
Frank, J., and Wagenknecht, T. (1984). Automatic selection of molecular images from electron micrographs. Ultramicroscopy 12, 169–176. PMID: PMCid:
Mannella, C.A., Colombini, M., and Frank, J. (1983). Structural and functional evidence for multiple channel complexes in the outer membrane of Neurospora crassa mitochondria. Proc Natl Acad Sci U S A 80, 2243-2247. PMID: 6300902; PMCid:
Zingsheim, H.P., Neugebauer, D.C., Frank, J., Hanicke, W., and Barrantes, F.J. (1982). Dimeric arrangement and structure of the membrane-bound acetylcholine receptor studied by electron microscopy. EMBO J 1, 541-547. PMID: 7188351; PMCid:
Zingsheim, H.P., Barrantes, F.J., Frank, J., Hanicke, W., and Neugebauer, D.C. (1982). Direct structural localization of two toxin-recognition sites on an ACh receptor protein. Nature 299, 81-84. PMID: 7110329; PMCid:
Sizaret, P.Y., Frank, J., Lamy, J., Weill, J., and Lamy, J.N. (1982). A refined quaternary structure of Androctonus australis Hemocyanin. Eur J Biochem 127, 501-506. PMID: 7173191; PMCid:
Mannella, C., and Frank, J. (1982). Effects of divalent metal ions and chelators on the structure of the outer mitochondrial membranes from Neurospora crassa. Biophysical Journal 37, 3-4. PMID: PMCid:
Lamy, J., Sizaret, P.Y., Frank, J., Verschoor, A., Feldmann, R., and Bonaventura, J. (1982). Architecture of Limulus polyphemus hemocyanin. Biochemistry 21, 6825-6833. PMID: 7159564; PMCid:
Frank, J., Verschoor, A., and Boublik, M. (1982). Multivariate statistical analysis of ribosome electron micrographs. L and R lateral views of the 40 S subunit from HeLa cells. J Mol Biol 161, 107-133. PMID: 6185684; PMCid:
Frank, J., and van Heel, M. (1982). Correspondence analysis of aligned images of biological particles. J Mol Biol 161, 134-137. PMID: 7154073; PMCid:
Frank, J. (1982). New methods for averaging non-periodic objects and distorted crystals in biologic electron microscopy. Optik 63, 67-89.
Frank, J. (1982). Methods for studying the dynamic behavior of biological macromolecules. Ultramicroscopy 9, 3-8. PMID: 7135629; PMCid:
van Heel, M., and Frank, J. (1981). Use of multivariate statistics in analysing the images of biological macromolecules. Ultramicroscopy 6, 187-194. PMID: 7268930; PMCid:
Frank, J., Verschoor, A., and Boublik, M. (1981). Computer averaging of electron micrographs of 40S ribosomal subunits. Science 214, 1353-1355. PMID: 7313694; PMCid:
Frank, J., Shimkin, B., and Dowse, H. (1981). SPIDER — A modular software system for image processing. Ultramicroscopy 6, 343-358.
Zingsheim, H.P., Neugebauer, D.C., Barrantes, F.J., and Frank, J. (1980). Structural details of membrane-bound acetylcholine receptor from Tropedo marmorata. Proc Natl Acad Sci U S A 77, 952-956. PMID: 6928692; PMCid:
Kessel, M., Frank, J., and Goldfarb, W. (1980). Averages of glutamine synthetase molecules as obtained with various skin and electron dose conditions. J Supramol Struct 14, 405-422. PMID: 6165866; PMCid:
Al-Ali, L., and Frank, J. (1980). Resolution estimation in electron microscopy. Optik 56, 31. PMID: PMCid:
Frank, J., Goldfarb, W., Eisenberg, D., and Baker, T.S. (1979). Addendum to “reconstruction of glutamine synthetase using computer averaging”. Ultramicroscopy 04, 247. PMID: 38551; PMCid:
Frank, J., McFarlane, S.C., and Downing, K.H. (1978). A note on the effect of source size and defocus spread in bright field electron microscopy. Optik 52, 49-60. PMID: PMCid:
Frank, J., Goldfarb, W., Eisenberg, D., and Baker, T.S. (1978). Reconstruction of glutamine synthetase using computer averaging. Ultramicroscopy 3, 283-290. PMID: 32653; PMCid:
Wade, R.H., and Frank, J. (1977). Electron microscopic transfer functions for partially coherent axial illumination and chromatic defocus spread. Optik 49, 81-92 PMID: PMCid:
Saxton, W.O., and Frank, J. (1977). Motif detection in quantum noise-limited electron micrographs by cross-correlation. Ultramicroscopy 2, 219-227. PMID: 888241; PMCid:
Frank, J. (1976). Determination of source size and energy spread from electron micrographs using the method of Young’s fringes. Optik 44, 379-391. PMID: PMCid:
Frank, J., and Al-Ali, L. (1975). Signal-to-noise ratio of electron micrographs obtained by cross correlation. Nature 256, 376-379. PMID: 1095934; PMCid:
Frank, J. (1975). Partial coherence and efficient use of electrons in bright field electron microscopy. Optik 43, 103-109. PMID: PMCid:
Frank, J. (1975). Controlled focusing and stigmating in the conventional and scanning transmission electron microscope. Journal of Physics E: Scientific Instruments 8, 582-587 PMID: PMCid:
Frank, J. (1975). A practical resolution criterion in optics and electron microscopy. Optik 43, 25-34. PMID: PMCid:
Frank, J. (1975). Averaging of low exposure electron micrographs of non-periodic objects. Ultramicroscopy 1, 159-162. PMID: 1236029; PMCid:
Frank, J. (1974/75). Phasenbestimmung and Beruecksichtigung der Linsenfehler in der Elektronenmikroskopie; eine Klarstellung. Optik 41, 90-91. PMID: PMCid:
Frank, J. (1974). Radiation damage assessment from electron images using digital correlation methods. Journal of Physics D: Applied Physics 7, L75-L78 PMID: PMCid:
Frank, J. (1973). A remark on phase determination in electron microscopy. Optik 38, 582-584. PMID: PMCid:
Frank, J. (1973). The envelope of electron microscopic transfer functions for partially coherent illumination. Optik 38, 519-539 PMID: PMCid:
Frank, J. (1972). Observation of the relative phases of electron microscopic phase contrast zones with the aid of the optical diffractometer. Optik 35, 608-612 PMID: PMCid:
Frank, J. (1972). A study of heavy-light atom discrimination in bright-field electron microscopy using the computer. Biophys J 12, 484-511. PMID: 5030562; PMCid:
Langer, R., Formanek, S., Frank, J., Martin, H.H., and Hoppe, W. (1969). [Structure of the murein sacculus of Spirillum serpens. Quantitative electron microscopy studies at high resolution]. Hoppe Seylers Z Physiol Chem 350, 1173-1174. PMID: 5352337; PMCid:
Hoppe, W., Langer, R., Frank, J., and Feltynowski, A. (1969). Bilddifferenzverfahren in der Elektronen-mikroskopie [Image differentiation procedures in electron microscopy]. Naturwissenschaften 56, 267-272. PMID: 5360874; PMCid:
Frank, J. (1969). Nachweis von Objektbewegungen im lichtoptischen Diffraktogramm von elektronenmikroskopischen Aufnahmen. Optik 30, 171-180 PMID: PMCid:
Frank, J. (2012). Intermediate states during mRNA–tRNA translocation. Curr Opin Struct Biol 22, 778-785. PMID: 22906732; PMCid: PMC3508672.
Frank, J. (2011). The Ribosome, a Restless Molecular Machine. In Asia Pacific Biotech News (APBN), pp. 29-32.
Liao, H., and Frank, J. (2010). Definition and estimation of resolution in single-particle reconstructions. Structure 18, 768-775. PMID: 20637413; NIHMS224229; PMCid: PMC2923553.
Frank, J., and Gonzalez, R.L. (2010). Structure and dynamics of a processive Brownian motor: the translating ribosome. Ann Rev Biochem 79, 381-412. PMID: 20235828; NIHMS223198; PMCid: PMC2917226.
Frank, J. (2010). The ribosome comes alive. Israel Journal of Chemistry 50, 95-98. PMID: NIHMS248376; PMCid: PMC2976627.
Agirrezabala, X., and Frank, J. (2010). From DNA to proteins via the ribosome. Structural insights into the workings of the translation machinery. Human Genomics 4, 226-237. PMID: 20511136; NIHMS248325; PMCid: PMC2976604.
Gao, H., LeBarron, J., and Frank, J. (2009). Ribosomal dynamics: intrinsic instability of a molecular machine. In Non-Protein Coding RNAs, N.G. Walter, S.A. Woodson, and R.T. Batey, eds. (Springer-Verlag Berlin), pp. 303-316.
Frank, J. (2009). Single-particle reconstruction of biological macromolecules in electron microscopy – 30 years. Q Rev Biophys 42, 139-158. PMID: 20025794; PMCid: PMC2844734
Agirrezabala, X., and Frank, J. (2009). Elongation in translation as a dynamic interaction among the ribosome, tRNA, and elongation factors EF-G and EF-Tu. Quart Rev Biophys 42, 159-200. PMID: 20025795; PMCid: PMC2832932.
Shaikh, T.R., Gao, H., Baxter, W.T., Asturias, F.J., Boisset, N., Leith, A., and Frank, J. (2008). SPIDER image processing for single-particle reconstruction of biological macromolecules from electron micrographs. Nat Protoc 3, 1941-1974. PMID: 19180078; NIHMS100948; PMCid: PMC2737740.
Grassucci, R.A., Taylor, D., and Frank, J. (2008). Visualization of macromolecular complexes using cryo-electron microscopy with FEI Tecnai transmission electron microscopes. Nat Protoc 3, 330-339. PMID: 18274535; NIHMS98616; PMCid: PMC2654234.
Frank, J. (2008). Under the Rug, or a Plea for the Lighter Touch. J Struct Biol 163, 270. PMID: 19255612; NIHMS72627; PMCid: PMC2577220.
Taylor, D.J., Frank, J., and Kinzy, T.G. (2007). Structure and function of the eukaryotic ribosome and elongation factors. In Translational Control in Biology and Medicine, M.B. Mathews, N. Sonenberg, and J.W.B. Hershey, eds. (Cold Spring Harbor Press), pp. 59-86.
Grassucci, R.A., Taylor, D.J., and Frank, J. (2007). Preparation of macromolecular complexes for cryo-electron microscopy. Nat Protoc 2, 3239-3246. PMID: 18079724; NIHMS98815; PMCid: PMC2710239.
Frank, J., Gao, H., Sengupta, J., Gao, N., and Taylor, D.J. (2007). The process of mRNA-tRNA translocation. Proc Natl Acad Sci U S A 104, 19671-19678. PMID: 18003906; PMCid: PMC2148355.
Allen, G.S., and Frank, J. (2007). Structural insights on the translation initiation complex: ghosts of a universal initiation complex. Mol Microbiol 63, 941-950. PMID: 17238926; PMCid:
Mitra, K., and Frank, J. (2006). Ribosome dynamics: insights from atomic structure modeling into cryo-electron microscopy maps. Annu Rev Biophys Biomol Struct 35, 299-317. PMID: 16689638; PMCid:
Gao, N., and Frank, J. (2006). A library of RNA bridges. Nat Chem Biol 2, 231-232. PMID: 16619019; PMCid:
Frank, J., and Spahn, C.M.T. (2006). The ribosome and the mechanism of protein synthesis. Reports on Progress in Physics 69, 1383-1417. PMID: PMCid:
Berman, H.M., Burley, S.K., Chiu, W., Sali, A., Adzhubei, A., Bourne, P.E., Bryant, S.H., Dunbrack, R.L., Jr., Fidelis, K., Frank, J., Godzik, A., Henrick, K., Joachimiak, A., Heymann, B., Jones, D., Markley, J.L., Moult, J., Montelione, G.T., Orengo, C., Rossmann, M.G., Rost, B., Saibil, H., Schwede, T., Standley, D.M., and Westbrook, J.D. (2006). Outcome of a workshop on archiving structural models of biological macromolecules. Structure 14, 1211-1217. PMID: 16955948; PMCid:
Frank, J., Sengupta, J., Gao, H., Li, W., Valle, M., Zavialov, A., and Ehrenberg, M. (2005). The role of tRNA as a molecular spring in decoding, accommodation, and peptidyl transfer. FEBS Lett 579, 959-962. PMID: 15680982; PMCid:
Frank, J. (2004). The dynamics of the ribosome as inferred by cryo-EM: induced and self-organized motions. In Conformational Proteomics of Macromolecular Architecture, R.H.Cheng, and L. Hammar, eds. (Singapore, World Scientific Publishing Co.), p. 291.
Frank, J., and Schlichting, I. (2004). Time-resolved imaging of macromolecular processes and interactions. J Struct Biol 147, 209-210. PMID: 15450290; PMCid:
Frank, J. (2003). Electron microscopy of functional ribosome complexes. Biopolymers 68, 223-233. PMID: 12548625; PMCid:
Frank, J. (2003). Toward an understanding of the structural basis of translation. Genome Biol 4, 237. PMID: 14659007; PMCid: 329409.
Frank, J., Wagenknecht, T., McEwen, B.F., Marko, M., Hsieh, C.E., and Mannella, C.A. (2002). Three-dimensional imaging of biological complexity. J Struct Biol 138, 85-91. PMID: 12160704; PMCid:
Frank, J. (2002). Single-particle imaging of macromolecules by cryo-electron microscopy. Annu Rev Biophys Biomol Struct 31, 303-319. PMID: 11988472; PMCid:
Frank, J. (2002). A cold look at transcription. Structure 10, 1156-1157. PMID: 12220487; PMCid:
Frank, J. (2001). Cryo-electron microscopy as an investigative tool: the ribosome as an example. Bioessays 23, 725-732. PMID: 11494321; PMCid:
Frank, J. (2001). Ribosomal dynamics explored by cryo-electron microscopy. Methods 25, 309-315. PMID: 11860285; PMCid:
VanLoock, M.S., Malhotra, A., Case, D.A., Agrawal, R.K., Penczek, P., Easterwood, T.R., Frank, J., and Harvey, S.C. (2000). Functional interpretation of the cryo-electron microscopy map of the 30S ribosomal subunit from Escherichia coli. In The Ribosome: Structure, Function, Antibiotics, and Cellular Interactions, R.A. Garrett, S.R. Douthwaite, A. Liljas, A.T. Matheson, P.B. Moore, and H.F. Noller, eds. (Washington, DC, ASM Press), pp. 165-171.
Frank, J., Penczek, P., Agrawal, R.K., Grassucci, R.A., and Heagle, A.B. (2000). Three-dimensional cryoelectron microscopy of ribosomes. Methods Enzymol 317, 276-291. PMID: 10829286; PMCid:
Frank, J. (2000). The ribosome–a macromolecular machine par excellence. Chem Biol 7, R133-141. PMID: 10873840; PMCid:
Agrawal, R.K., Heagle, A.B., and Frank, J. (2000). Studies of elongation factor G-dependent tRNA translocation by three-dimensional cryo-electron microscopy. In The Ribosome: Structure, Function, Antibiotics, and Cellular Interactions, R.A. Garrett, S.R. Douthwaite, A. Liljas, A.T. Matheson, P.B. Moore, and H.F. Noller, eds. (Washington, DC, ASM Press), pp. 53-62.
Penczek, P., Ban, N., Grassucci, R.A., Agrawal, R.K., and Frank, J. (1999). Haloarcula marismortui 50S subunit-complementarity of electron microscopy and X-Ray crystallographic information. J Struct Biol 128, 44-50. PMID: 10600557; PMCid:
Malhotra, A., and Frank, J. (1999). Predicting three-dimensional structure of ribosomal RNA using cryo electron microscopy maps of the Escherichia coli ribosome. Nucleic Acids Symposium Series 41, 32-34. PMID: PMCid:
Agrawal, R.K., Lata, R.K., and Frank, J. (1999). Conformational variability in Escherichia coli 70S ribosome as revealed by 3D cryo-electron microscopy. Int J Biochem Cell Biol 31, 243-254. PMID: 10216957; PMCid:
Agrawal, R.K., and Frank, J. (1999). Structural studies of the translational apparatus. Curr Opin Struct Biol 9, 215-221. PMID: 10322215; PMCid:
Frank, J. (1998). How the ribosome works. American Scientist 86, 428-439. PMID: PMCid:
Frank, J. (1998). The ribosome-structure and functional ligand-binding experiments using cryo-electron microscopy. J Struct Biol 124, 142-150. PMID: 10049802; PMCid:
Penczek, P.A., Zhu, J., Schröder, R., and Frank, J. (1997). Three dimensional reconstruction with contrast transfer compensation from defocus series. Scanning Microscopy 11, 147-154. PMID: PMCid:
Frank, J. (1997). The ribosome at higher resolution–the donut takes shape. Curr Opin Struct Biol 7, 266-272. PMID: 9094327; PMCid:
Frank, J., Verschoor, A., Li, Y., Zhu, J., Lata, R.K., Radermacher, M., Penczek, P., Grassucci, R., Agrawal, R.K., and Srivastava, S. (1995). A model of the translational apparatus based on a three-dimensional reconstruction of the Escherichia coli ribosome. Biochem Cell Biol 73, 757-765. PMID: 8721992; PMCid:
Frank, J. (1995). Approaches to large-scale structures. Curr Opin Struct Biol 5, 194-201. PMID: 7648321; PMCid:
Verschoor, A., Srivastava, S., Radermacher, M., Frank, J., Traut, R., Stöffler-Meilicke, M., and Glitz, D. (1993). Functional site determinations in three dimensions on eukaryotic and eubacterial ribosomes. In The Translational Apparatus, K.H. Nierhaus, F. Franceschi, A.R. Subramanian, V.A. Erdmann, and B. Wittmann-Liebold, eds. (New York, Plenum Press).
Frank, J., Chiu, W., and Henderson, R. (1993). Flopping polypeptide chains and Suleika’s subtle imperfections: analysis of variations in the electron micrograph of a purple membrane crystal. Ultramicroscopy 49, 387-396. PMID: 8475603; PMCid:
Frank, J., Penczek, P., and Liu, W. (1992). Alignment, classification, and 3-D reconstruction of single particles embedded in ice. Paper presented at: Proc X Pfefferkorn Conference on Image and Signal Processing (Scanning Suppl. ).
Frank, J., Penczek, P., and Liu, W. (1992). Alignment, classification, and three-dimensional reconstruction of single particles embedded in ice. Scanning Microsc Suppl 6, 11-20; discussion 20-12. PMID: 1366339; PMCid:
Frank, J. (1992). Three-dimensional reconstruction at the molecular level. Microscopy, Microanalysis, Microstructures 3, 45-54. PMID: PMCid:
Turner, J.N., Frank, J., and Rieder, C.L. (1990). Biological Microscopy and Image Reconstruction Resources. EMSA Bulletin 20, 127-130. PMID: PMCid:
Frank, J., Verschoor, A., Radermacher, M., and Wagenknecht, T. (1990). Morphologies of eubacterial and eukaryotic ribosomes as determined by three-dimensional electron microscopy. In The Ribosome W.E. Hill, A. Dahlberg, R.A. Garrett, P.B. Moore, D. Schlesinger, and J.R.Warner, eds. (Washington, DC, American Society for Microbiology), pp. 107-113.
Frank, J., and Radermacher, M. (1990). Three-dimensional reconstruction of single particles negatively stained or in vitreous ice. Paper presented at: Proc Workshop on Quantitative Electron Microscopy (Schloss Ringberg, Rottach-Egern, Germany Ultramicroscopy ).
Frank, J. (1990). Classification of macromolecular assemblies studied as ‘single particles’. Q Rev Biophys 23, 281-329. PMID: 2204955; PMCid:
Frank, J. (1989). Image analysis of single macromolecules. Electron Microsc Rev 2, 53-74. PMID: 2491342; PMCid:
Frank, J. (1989). Three-dimensional imaging techniques in electron microscopy. Biotechniques 7, 164-173. PMID: 2698195; PMCid:
Frank, J., Verschoor, A., Wagenknecht, T., Radermacher, M., and Carazo, J.M. (1988). A new non-crystallographic image-processing technique reveals the architecture of ribosomes. Trends Biochem Sci 13, 123-127. PMID: 3075375; PMCid:
Frank, J., McEwen, B.F., Radermacher, M., Turner, J.N., and Rieder, C.L. (1987). Three-dimensional tomographic reconstruction in high voltage electron microscopy. Journal of Electron Microscopy Technique 6, 193-205. PMID: PMCid:
Frank, J., and Mannella, C. (1987). New avenues in electron microscopy of transmembraneous biomolecular assemblies. In Advances in Membrane Biochemistry and Bioenergetics, C.H. Kim, and T.E. King, eds. (Plenum Publishing Corporation), pp. 459-467.
Frank, J., Radermacher, M., Wagenknecht, T., and Verschoor, A. (1986). A new method for three-dimensional reconstruction of single macromolecules using low-dose electron micrographs. Ann N Y Acad Sci 483, 77-87. PMID: 3551727; PMCid:
Frank, J., McEwen, B., Radermacher, M., Turner, J.N., and Rieder, C.L. (1986). Three-dimensional tomographic reconstruction in high voltage electron microscopy (Kyoto, Proc. 11th Int. Congr. Electron Microscopy ).
Frank, J., McEwen, B., Radermacher, M., and Rieder, C.L. (1986). Methods for three-dimensional reconstruction of cellular components within a thick section (Proc 44th annual meeting EMSA).
Boublik, M., Oostergetel, G.T., Wall, J.S., Hainfeld, J.F., Radermacher, M., Wagenknecht, T., Verschoor, A., and Frank, J. (1986). Structure of ribosomes and their components by advanced techniques of electron microscopy and computer image analysis. In Structure, Function and Genetics of Ribosomes B. Hardesty, and G. Kramer, eds. (New York), pp. 68-86.
Mannella, C.A., and Frank, J. (1984). Negative staining characteristics of arrays of mitochondrial pore protein: use of correspondence analysis to classify different staining patterns. Ultramicroscopy 13, 93-102. PMID: 6206632; PMCid:
Frank, J. (1984). Recent advances of image processing in the structural analysis of biological macromolecules. Paper presented at: 8th Europ Congr El Microsc (Budapest).
Frank, J. (1984). Quantitative study of macromolecular assemblies with the aid of correlation alignment, multivariate image analysis, and three dimensional reconstruction. Paper presented at: 8th Int Biophysics Congress (Bristol).
Frank, J. (1984). The role of multivariate image analysis in solving the architecture of the Limulus polyphemus hemocyanin molecule. Ultramicroscopy 13, 153-164. PMID: 6474597; PMCid:
Subirana, J.A., Munoz-Guerra, S., Radermacher, M., and Frank, J. (1983). Three-dimensional reconstruction of chromatin fibers. J Biomol Struct Dyn 1, 705-714. PMID: 6400895; PMCid:
Frank, J., and Van Heel, M. (1982). Averaging techniques and correspondence analysis (Proceedings of the 10th International Congress on Electron Microscopy).
Frank, J. (1982). Differential averaging of single molecule images using multivariate statistical classification. Paper presented at: Meeting EMSA (Proc. 40th Ann).
Van Heel, M., and Frank, J. (1980). Classification of particles in noisy electron micrographs by using correspondence analysis. In Pattern Recognition in Practice, E.S. Gelsema, and L. Kanal, eds. (Amsterdam, North Holland), pp. 235-245
Kessel, M., Frank, J., and Goldfarb, W. (1980). Low dose electron microscopy of individual biological macromolecules. In Electron Microscopy at Molecular Dimensions State of the Art and Strategies for the Future, W. Baumeister, ed. (Berlin, Springer ), pp. 154-160
Frank, J., and Goldfarb, W. (1980). Methods of averaging of single molecules and lattice fragments. In Electron Microscopy at Molecular Dimensions State of the Art and Strategies for the Future, W. Baumeister, ed. (Berlin, Springer), pp. 261-269
Frank, J. (1979). Image analysis in electron microscopy. Journal of Microscopy 117, 25-38. PMID: PMCid:
Goldfarb, W., Frank, J., Kessel, M., Hsung, J.C., Kim, C.H., and King, T.E. (1978). Cytochrome oxidase vesicles with two dimensional order. Paper presented at: Intl Symp Cytochrome Oxidase (Mt. Rokossan, Kobe, Japan, Elsevier).
Frank, J. (1978). Optimum use of image information using signal detection and averaging techniques. Annals of the New York Academy of Sciences 306, 112-120 PMID: PMCid:
Frank, J. (1975). Report on OSA topical meeting on image processing. In Appl Optics (Stanford University), pp. 2782-2784 PMID: PMCid:
Beer, M., Frank, J., Hanszen, K.J., Kellenberger, E., and Williams, R.C. (1974). The possibilities and prospects of obtaining high-resolution information (below 30 A) on biological material using the electron microscope. Some comments and reports inspired by an EMBO workshop held at Gais, Switzerland, October 1973. Q Rev Biophys 7, 211-238. PMID: 4615338; PMCid:
Frank, J. (2011). The Ribosome, a Restless Molecular Machine. In Asia Pacific Biotech News (APBN), pp. 29-32.
Liao, H., and Frank, J. (2010). Definition and estimation of resolution in single-particle reconstructions. Structure 18, 768-775. PMID: 20637413; NIHMS224229; PMCid: PMC2923553.
Frank, J., and Gonzalez, R.L. (2010). Structure and dynamics of a processive Brownian motor: the translating ribosome. Ann Rev Biochem 79, 381-412. PMID: 20235828; NIHMS223198; PMCid: PMC2917226.
Frank, J. (2010). The ribosome comes alive. Israel Journal of Chemistry 50, 95-98. PMID: NIHMS248376; PMCid: PMC2976627.
Agirrezabala, X., and Frank, J. (2010). From DNA to proteins via the ribosome. Structural insights into the workings of the translation machinery. Human Genomics 4, 226-237. PMID: 20511136; NIHMS248325; PMCid: PMC2976604.
Gao, H., LeBarron, J., and Frank, J. (2009). Ribosomal dynamics: intrinsic instability of a molecular machine. In Non-Protein Coding RNAs, N.G. Walter, S.A. Woodson, and R.T. Batey, eds. (Springer-Verlag Berlin), pp. 303-316.
Frank, J. (2009). Single-particle reconstruction of biological macromolecules in electron microscopy – 30 years. Q Rev Biophys 42, 139-158. PMID: 20025794; PMCid: PMC2844734
Agirrezabala, X., and Frank, J. (2009). Elongation in translation as a dynamic interaction among the ribosome, tRNA, and elongation factors EF-G and EF-Tu. Quart Rev Biophys 42, 159-200. PMID: 20025795; PMCid: PMC2832932.
Shaikh, T.R., Gao, H., Baxter, W.T., Asturias, F.J., Boisset, N., Leith, A., and Frank, J. (2008). SPIDER image processing for single-particle reconstruction of biological macromolecules from electron micrographs. Nat Protoc 3, 1941-1974. PMID: 19180078; NIHMS100948; PMCid: PMC2737740.
Grassucci, R.A., Taylor, D., and Frank, J. (2008). Visualization of macromolecular complexes using cryo-electron microscopy with FEI Tecnai transmission electron microscopes. Nat Protoc 3, 330-339. PMID: 18274535; NIHMS98616; PMCid: PMC2654234.
Frank, J. (2008). Under the Rug, or a Plea for the Lighter Touch. J Struct Biol 163, 270. PMID: 19255612; NIHMS72627; PMCid: PMC2577220.
Taylor, D.J., Frank, J., and Kinzy, T.G. (2007). Structure and function of the eukaryotic ribosome and elongation factors. In Translational Control in Biology and Medicine, M.B. Mathews, N. Sonenberg, and J.W.B. Hershey, eds. (Cold Spring Harbor Press), pp. 59-86.
Grassucci, R.A., Taylor, D.J., and Frank, J. (2007). Preparation of macromolecular complexes for cryo-electron microscopy. Nat Protoc 2, 3239-3246. PMID: 18079724; NIHMS98815; PMCid: PMC2710239.
Frank, J., Gao, H., Sengupta, J., Gao, N., and Taylor, D.J. (2007). The process of mRNA-tRNA translocation. Proc Natl Acad Sci U S A 104, 19671-19678. PMID: 18003906; PMCid: PMC2148355.
Allen, G.S., and Frank, J. (2007). Structural insights on the translation initiation complex: ghosts of a universal initiation complex. Mol Microbiol 63, 941-950. PMID: 17238926; PMCid:
Mitra, K., and Frank, J. (2006). Ribosome dynamics: insights from atomic structure modeling into cryo-electron microscopy maps. Annu Rev Biophys Biomol Struct 35, 299-317. PMID: 16689638; PMCid:
Gao, N., and Frank, J. (2006). A library of RNA bridges. Nat Chem Biol 2, 231-232. PMID: 16619019; PMCid:
Frank, J., and Spahn, C.M.T. (2006). The ribosome and the mechanism of protein synthesis. Reports on Progress in Physics 69, 1383-1417. PMID: PMCid:
Berman, H.M., Burley, S.K., Chiu, W., Sali, A., Adzhubei, A., Bourne, P.E., Bryant, S.H., Dunbrack, R.L., Jr., Fidelis, K., Frank, J., Godzik, A., Henrick, K., Joachimiak, A., Heymann, B., Jones, D., Markley, J.L., Moult, J., Montelione, G.T., Orengo, C., Rossmann, M.G., Rost, B., Saibil, H., Schwede, T., Standley, D.M., and Westbrook, J.D. (2006). Outcome of a workshop on archiving structural models of biological macromolecules. Structure 14, 1211-1217. PMID: 16955948; PMCid:
Frank, J., Sengupta, J., Gao, H., Li, W., Valle, M., Zavialov, A., and Ehrenberg, M. (2005). The role of tRNA as a molecular spring in decoding, accommodation, and peptidyl transfer. FEBS Lett 579, 959-962. PMID: 15680982; PMCid:
Frank, J. (2004). The dynamics of the ribosome as inferred by cryo-EM: induced and self-organized motions. In Conformational Proteomics of Macromolecular Architecture, R.H.Cheng, and L. Hammar, eds. (Singapore, World Scientific Publishing Co.), p. 291.
Frank, J., and Schlichting, I. (2004). Time-resolved imaging of macromolecular processes and interactions. J Struct Biol 147, 209-210. PMID: 15450290; PMCid:
Frank, J. (2003). Electron microscopy of functional ribosome complexes. Biopolymers 68, 223-233. PMID: 12548625; PMCid:
Frank, J. (2003). Toward an understanding of the structural basis of translation. Genome Biol 4, 237. PMID: 14659007; PMCid: 329409.
Frank, J., Wagenknecht, T., McEwen, B.F., Marko, M., Hsieh, C.E., and Mannella, C.A. (2002). Three-dimensional imaging of biological complexity. J Struct Biol 138, 85-91. PMID: 12160704; PMCid:
Frank, J. (2002). Single-particle imaging of macromolecules by cryo-electron microscopy. Annu Rev Biophys Biomol Struct 31, 303-319. PMID: 11988472; PMCid:
Frank, J. (2002). A cold look at transcription. Structure 10, 1156-1157. PMID: 12220487; PMCid:
Frank, J. (2001). Cryo-electron microscopy as an investigative tool: the ribosome as an example. Bioessays 23, 725-732. PMID: 11494321; PMCid:
Frank, J. (2001). Ribosomal dynamics explored by cryo-electron microscopy. Methods 25, 309-315. PMID: 11860285; PMCid:
VanLoock, M.S., Malhotra, A., Case, D.A., Agrawal, R.K., Penczek, P., Easterwood, T.R., Frank, J., and Harvey, S.C. (2000). Functional interpretation of the cryo-electron microscopy map of the 30S ribosomal subunit from Escherichia coli. In The Ribosome: Structure, Function, Antibiotics, and Cellular Interactions, R.A. Garrett, S.R. Douthwaite, A. Liljas, A.T. Matheson, P.B. Moore, and H.F. Noller, eds. (Washington, DC, ASM Press), pp. 165-171.
Frank, J., Penczek, P., Agrawal, R.K., Grassucci, R.A., and Heagle, A.B. (2000). Three-dimensional cryoelectron microscopy of ribosomes. Methods Enzymol 317, 276-291. PMID: 10829286; PMCid:
Frank, J. (2000). The ribosome–a macromolecular machine par excellence. Chem Biol 7, R133-141. PMID: 10873840; PMCid:
Agrawal, R.K., Heagle, A.B., and Frank, J. (2000). Studies of elongation factor G-dependent tRNA translocation by three-dimensional cryo-electron microscopy. In The Ribosome: Structure, Function, Antibiotics, and Cellular Interactions, R.A. Garrett, S.R. Douthwaite, A. Liljas, A.T. Matheson, P.B. Moore, and H.F. Noller, eds. (Washington, DC, ASM Press), pp. 53-62.
Penczek, P., Ban, N., Grassucci, R.A., Agrawal, R.K., and Frank, J. (1999). Haloarcula marismortui 50S subunit-complementarity of electron microscopy and X-Ray crystallographic information. J Struct Biol 128, 44-50. PMID: 10600557; PMCid:
Malhotra, A., and Frank, J. (1999). Predicting three-dimensional structure of ribosomal RNA using cryo electron microscopy maps of the Escherichia coli ribosome. Nucleic Acids Symposium Series 41, 32-34. PMID: PMCid:
Agrawal, R.K., Lata, R.K., and Frank, J. (1999). Conformational variability in Escherichia coli 70S ribosome as revealed by 3D cryo-electron microscopy. Int J Biochem Cell Biol 31, 243-254. PMID: 10216957; PMCid:
Agrawal, R.K., and Frank, J. (1999). Structural studies of the translational apparatus. Curr Opin Struct Biol 9, 215-221. PMID: 10322215; PMCid:
Frank, J. (1998). How the ribosome works. American Scientist 86, 428-439. PMID: PMCid:
Frank, J. (1998). The ribosome-structure and functional ligand-binding experiments using cryo-electron microscopy. J Struct Biol 124, 142-150. PMID: 10049802; PMCid:
Penczek, P.A., Zhu, J., Schröder, R., and Frank, J. (1997). Three dimensional reconstruction with contrast transfer compensation from defocus series. Scanning Microscopy 11, 147-154. PMID: PMCid:
Frank, J. (1997). The ribosome at higher resolution–the donut takes shape. Curr Opin Struct Biol 7, 266-272. PMID: 9094327; PMCid:
Frank, J., Verschoor, A., Li, Y., Zhu, J., Lata, R.K., Radermacher, M., Penczek, P., Grassucci, R., Agrawal, R.K., and Srivastava, S. (1995). A model of the translational apparatus based on a three-dimensional reconstruction of the Escherichia coli ribosome. Biochem Cell Biol 73, 757-765. PMID: 8721992; PMCid:
Frank, J. (1995). Approaches to large-scale structures. Curr Opin Struct Biol 5, 194-201. PMID: 7648321; PMCid:
Verschoor, A., Srivastava, S., Radermacher, M., Frank, J., Traut, R., Stöffler-Meilicke, M., and Glitz, D. (1993). Functional site determinations in three dimensions on eukaryotic and eubacterial ribosomes. In The Translational Apparatus, K.H. Nierhaus, F. Franceschi, A.R. Subramanian, V.A. Erdmann, and B. Wittmann-Liebold, eds. (New York, Plenum Press).
Frank, J., Chiu, W., and Henderson, R. (1993). Flopping polypeptide chains and Suleika’s subtle imperfections: analysis of variations in the electron micrograph of a purple membrane crystal. Ultramicroscopy 49, 387-396. PMID: 8475603; PMCid:
Frank, J., Penczek, P., and Liu, W. (1992). Alignment, classification, and 3-D reconstruction of single particles embedded in ice. Paper presented at: Proc X Pfefferkorn Conference on Image and Signal Processing (Scanning Suppl. ).
Frank, J., Penczek, P., and Liu, W. (1992). Alignment, classification, and three-dimensional reconstruction of single particles embedded in ice. Scanning Microsc Suppl 6, 11-20; discussion 20-12. PMID: 1366339; PMCid:
Frank, J. (1992). Three-dimensional reconstruction at the molecular level. Microscopy, Microanalysis, Microstructures 3, 45-54. PMID: PMCid:
Turner, J.N., Frank, J., and Rieder, C.L. (1990). Biological Microscopy and Image Reconstruction Resources. EMSA Bulletin 20, 127-130. PMID: PMCid:
Frank, J., Verschoor, A., Radermacher, M., and Wagenknecht, T. (1990). Morphologies of eubacterial and eukaryotic ribosomes as determined by three-dimensional electron microscopy. In The Ribosome W.E. Hill, A. Dahlberg, R.A. Garrett, P.B. Moore, D. Schlesinger, and J.R.Warner, eds. (Washington, DC, American Society for Microbiology), pp. 107-113.
Frank, J., and Radermacher, M. (1990). Three-dimensional reconstruction of single particles negatively stained or in vitreous ice. Paper presented at: Proc Workshop on Quantitative Electron Microscopy (Schloss Ringberg, Rottach-Egern, Germany Ultramicroscopy ).
Frank, J. (1990). Classification of macromolecular assemblies studied as ‘single particles’. Q Rev Biophys 23, 281-329. PMID: 2204955; PMCid:
Frank, J. (1989). Image analysis of single macromolecules. Electron Microsc Rev 2, 53-74. PMID: 2491342; PMCid:
Frank, J. (1989). Three-dimensional imaging techniques in electron microscopy. Biotechniques 7, 164-173. PMID: 2698195; PMCid:
Frank, J., Verschoor, A., Wagenknecht, T., Radermacher, M., and Carazo, J.M. (1988). A new non-crystallographic image-processing technique reveals the architecture of ribosomes. Trends Biochem Sci 13, 123-127. PMID: 3075375; PMCid:
Frank, J., McEwen, B.F., Radermacher, M., Turner, J.N., and Rieder, C.L. (1987). Three-dimensional tomographic reconstruction in high voltage electron microscopy. Journal of Electron Microscopy Technique 6, 193-205. PMID: PMCid:
Frank, J., and Mannella, C. (1987). New avenues in electron microscopy of transmembraneous biomolecular assemblies. In Advances in Membrane Biochemistry and Bioenergetics, C.H. Kim, and T.E. King, eds. (Plenum Publishing Corporation), pp. 459-467.
Frank, J., Radermacher, M., Wagenknecht, T., and Verschoor, A. (1986). A new method for three-dimensional reconstruction of single macromolecules using low-dose electron micrographs. Ann N Y Acad Sci 483, 77-87. PMID: 3551727; PMCid:
Frank, J., McEwen, B., Radermacher, M., Turner, J.N., and Rieder, C.L. (1986). Three-dimensional tomographic reconstruction in high voltage electron microscopy (Kyoto, Proc. 11th Int. Congr. Electron Microscopy ).
Frank, J., McEwen, B., Radermacher, M., and Rieder, C.L. (1986). Methods for three-dimensional reconstruction of cellular components within a thick section (Proc 44th annual meeting EMSA).
Boublik, M., Oostergetel, G.T., Wall, J.S., Hainfeld, J.F., Radermacher, M., Wagenknecht, T., Verschoor, A., and Frank, J. (1986). Structure of ribosomes and their components by advanced techniques of electron microscopy and computer image analysis. In Structure, Function and Genetics of Ribosomes B. Hardesty, and G. Kramer, eds. (New York), pp. 68-86.
Mannella, C.A., and Frank, J. (1984). Negative staining characteristics of arrays of mitochondrial pore protein: use of correspondence analysis to classify different staining patterns. Ultramicroscopy 13, 93-102. PMID: 6206632; PMCid:
Frank, J. (1984). Recent advances of image processing in the structural analysis of biological macromolecules. Paper presented at: 8th Europ Congr El Microsc (Budapest).
Frank, J. (1984). Quantitative study of macromolecular assemblies with the aid of correlation alignment, multivariate image analysis, and three dimensional reconstruction. Paper presented at: 8th Int Biophysics Congress (Bristol).
Frank, J. (1984). The role of multivariate image analysis in solving the architecture of the Limulus polyphemus hemocyanin molecule. Ultramicroscopy 13, 153-164. PMID: 6474597; PMCid:
Subirana, J.A., Munoz-Guerra, S., Radermacher, M., and Frank, J. (1983). Three-dimensional reconstruction of chromatin fibers. J Biomol Struct Dyn 1, 705-714. PMID: 6400895; PMCid:
Frank, J., and Van Heel, M. (1982). Averaging techniques and correspondence analysis (Proceedings of the 10th International Congress on Electron Microscopy).
Frank, J. (1982). Differential averaging of single molecule images using multivariate statistical classification. Paper presented at: Meeting EMSA (Proc. 40th Ann).
Van Heel, M., and Frank, J. (1980). Classification of particles in noisy electron micrographs by using correspondence analysis. In Pattern Recognition in Practice, E.S. Gelsema, and L. Kanal, eds. (Amsterdam, North Holland), pp. 235-245
Kessel, M., Frank, J., and Goldfarb, W. (1980). Low dose electron microscopy of individual biological macromolecules. In Electron Microscopy at Molecular Dimensions State of the Art and Strategies for the Future, W. Baumeister, ed. (Berlin, Springer ), pp. 154-160
Frank, J., and Goldfarb, W. (1980). Methods of averaging of single molecules and lattice fragments. In Electron Microscopy at Molecular Dimensions State of the Art and Strategies for the Future, W. Baumeister, ed. (Berlin, Springer), pp. 261-269
Frank, J. (1979). Image analysis in electron microscopy. Journal of Microscopy 117, 25-38. PMID: PMCid:
Goldfarb, W., Frank, J., Kessel, M., Hsung, J.C., Kim, C.H., and King, T.E. (1978). Cytochrome oxidase vesicles with two dimensional order. Paper presented at: Intl Symp Cytochrome Oxidase (Mt. Rokossan, Kobe, Japan, Elsevier).
Frank, J. (1978). Optimum use of image information using signal detection and averaging techniques. Annals of the New York Academy of Sciences 306, 112-120 PMID: PMCid:
Frank, J. (1975). Report on OSA topical meeting on image processing. In Appl Optics (Stanford University), pp. 2782-2784 PMID: PMCid:
Beer, M., Frank, J., Hanszen, K.J., Kellenberger, E., and Williams, R.C. (1974). The possibilities and prospects of obtaining high-resolution information (below 30 A) on biological material using the electron microscope. Some comments and reports inspired by an EMBO workshop held at Gais, Switzerland, October 1973. Q Rev Biophys 7, 211-238. PMID: 4615338; PMCid:
Frank, J. (2011). Molecular Machines in Biology: Workshop of the Cell (Cambridge University Press).
Glaeser, R.M., Downing, K., Chiu, W., Frank, J., and DeRosier, D. (2007). Electron Crystallography of Biological Macromolecules (Oxford University Press).
Frank, J. (2006). Electron Tomography, II edn (New York, Springer).
Frank, J. (2006). Three-Dimensional Electron Microscopy of Macromolecular Assemblies (New York, Oxford U. Press).
Frank, J. (1996). Three-dimensional Electron Microscopy of Macromolecular Assemblies (San Diego, Academic Press).
Frank, J. (1992). Electron Tomography: Three-Dimensional Imaging with the Transmission Electron Microscope (New York, Plenum Publishing Corp.).
Glaeser, R.M., Downing, K., Chiu, W., Frank, J., and DeRosier, D. (2007). Electron Crystallography of Biological Macromolecules (Oxford University Press).
Frank, J. (2006). Electron Tomography, II edn (New York, Springer).
Frank, J. (2006). Three-Dimensional Electron Microscopy of Macromolecular Assemblies (New York, Oxford U. Press).
Frank, J. (1996). Three-dimensional Electron Microscopy of Macromolecular Assemblies (San Diego, Academic Press).
Frank, J. (1992). Electron Tomography: Three-Dimensional Imaging with the Transmission Electron Microscope (New York, Plenum Publishing Corp.).
Frank, J. (2011). Ribosome dynamics: Progress in the characterization of mRNA-tRNA translocation by cryo-electron microscopy. In Ribosomes: Structure, Function, and Dynamics, M. Rodnina, Wintermeyer, W., Green, R., ed. (Springer).
Leith, A., Baxter, W.T., and Frank, J. (2010). Use of SPIDER and SPIRE in Image Reconstruction. In International Tables for Crystallography, M.G. Rossmann, Arnold, E., Himmel, D.M., ed.
Gao, H., LeBarron, J., and Frank, J. (2009). Ribosomal dynamics: intrinsic instability of a molecular machine. In Non-Protein Coding RNAs, N.G. Walter, S.A. Woodson, and R.T. Batey, eds. (Springer-Verlag Berlin), pp. 303-316.
Taylor, D.J., Frank, J., and Kinzy, T.G. (2007). Structure and function of the eukaryotic ribosome and elongation factors. In Translational Control in Biology and Medicine, M.B. Mathews, N. Sonenberg, and J.W.B. Hershey, eds. (Cold Spring Harbor Press), pp. 59-86.
Sengupta, J., and Frank, J. (2006). Cryo-electron microscopy as a tool to study molecular machines. In Protein Structures: Methods in Protein Structure and Stability Analysis (Hauppauge, NY Nova Science Publishers, Inc.).
Penczek, P.A., and Frank, J. (2006). Resolution in Electron Tomography. In Electron Tomography, J. Frank, ed. (New York, Springer Verlag).
Frank, J., and Agrawal, R.K. (2001). Ratchet-like movements between the two ribosomal subunits: their implications in elongation factor recognition and tRNA translocation. Cold Spring Harbor Symposia on Quantitative Biology 66, 67-75. PMID: 12762009; PMCid:
Beckmann, R., Spahn, C.M., Frank, J., and Blobel, G. (2001). The active 80S ribosome-Sec61 complex. Cold Spring Harbor Symposia on Quantitative Biology 66, 543-554. PMID: 12762056; PMCid:
Frank, J., Penczek, P., Grassucci, R.A., Heagle, A., Spahn, C.M.T., and Agrawal, R.K. (2000). Cryo-electron microscopy of the translational apparatus: Experimental evidence for the paths of mRNA, tRNA, and the polypeptide chain. In The Ribosome: Structure, Function, Antibiotics, and Cellular Interactions, R.A. Garrett, S.R. Douthwaite, A. Liljas, A.T. Matheson, P.B. Moore, and H.F. Noller, eds. (Washington, DC, ASM Press).
Frank, J., Penczek, P., Agrawal, R.K., Grassucci, R.A., and Heagle, A.B. (2000). Three-dimensional cryoelectron microscopy of ribosomes. In Three-dimensional cryoelectron microscopy of ribosomes, D.W. Celander, and J.N. Abelson, eds. (San Diego, CA, Academic Press), pp. 276-291.
Frank, J., Agrawal, R.K., and Verschoor, A. (2000). The structure of the ribosome. In Encyclopedia of Life Sciences (Macmillan Press), p. Article No. A534.
Frank, J., and Agrawal, R.K. (2000). Bacterial ribosomes. In Encyclopedia of Life Sciences (Macmillan Press), pp. Article No. A305, http://www.els.net/elsonline/html/A0000305.html.
Frank, J., and McEwen, B.F. (1992). Alignment by cross-correlation. In Electron Tomography, J. Frank, ed. (New York, Plenum), pp. 205-213.
Frank, J. (1992). Introduction. In Electron Tomography, J. Frank, ed. (New York, Plenum), pp. 1-13.
Frank, J., Radermacher, M., Wagenknecht, T., and Verschoor, A. (1988). Methods for studying ribosome structure by electron microscopy and computer image processing. In Methods in Enzymology K. Moldave, ed. (New York, Academic Press), pp. 3-35.
Frank, J., and Radermacher, M. (1986). Three dimensional reconstruction of biomolecular assemblies. In Advanced Techniques in Biological Electron Microscopy J.K. Koehler, ed. (Berlin, Springer Verlag), pp. 1-72.
Frank, J., Verschoor, A., and Wagenknecht, T. (1985). Computer processing of electron microscopic images of single macromolecules. In New Methodologies in Studies of Protein Conformation, T.T. Wu, ed. (New York, Von Nostrand Reinhold, Inc.), pp. 36-89.
Frank, J. (1980). Introduction to quantitative methods of reconstruction. In Methods and Perspectives in Cell Biology: Three Dimensional Ultra-Structure in Biology, J.N. Turner, ed. (New York, Academic Press), pp. 325-344.
Frank, J. (1980). Introduction to quantitative methods of reconstruction. In Methods and Perspectives in Cell Biology: Three Dimensional Ultra-Structure in Biology, J.N. Turner, ed. (New York, Academic Press), pp. 199-213.
Frank, J. (1980). The role of correlation techniques in computer image processing. In Computer Processing of Electron Micrographs P.W. Hawkes, ed. (Heidelberg, Springer Verlag), pp. 187-222.
Frank, J. (1973). Use of anomalous scattering for element discrimination. In Image Processing and Computer-Aided Design in Electron Optics, P.W. Hawkes, ed. (New York, Academic Press), pp. 196-211
Frank, J. (1973). Computer processing of electron micrographs. In Advanced Techniques in Biological Electron Microscopy, J.K. Koehler, ed. (Heidelberg, Springer Verlag ), pp. 215-274.
Leith, A., Baxter, W.T., and Frank, J. (2010). Use of SPIDER and SPIRE in Image Reconstruction. In International Tables for Crystallography, M.G. Rossmann, Arnold, E., Himmel, D.M., ed.
Gao, H., LeBarron, J., and Frank, J. (2009). Ribosomal dynamics: intrinsic instability of a molecular machine. In Non-Protein Coding RNAs, N.G. Walter, S.A. Woodson, and R.T. Batey, eds. (Springer-Verlag Berlin), pp. 303-316.
Taylor, D.J., Frank, J., and Kinzy, T.G. (2007). Structure and function of the eukaryotic ribosome and elongation factors. In Translational Control in Biology and Medicine, M.B. Mathews, N. Sonenberg, and J.W.B. Hershey, eds. (Cold Spring Harbor Press), pp. 59-86.
Sengupta, J., and Frank, J. (2006). Cryo-electron microscopy as a tool to study molecular machines. In Protein Structures: Methods in Protein Structure and Stability Analysis (Hauppauge, NY Nova Science Publishers, Inc.).
Penczek, P.A., and Frank, J. (2006). Resolution in Electron Tomography. In Electron Tomography, J. Frank, ed. (New York, Springer Verlag).
Frank, J., and Agrawal, R.K. (2001). Ratchet-like movements between the two ribosomal subunits: their implications in elongation factor recognition and tRNA translocation. Cold Spring Harbor Symposia on Quantitative Biology 66, 67-75. PMID: 12762009; PMCid:
Beckmann, R., Spahn, C.M., Frank, J., and Blobel, G. (2001). The active 80S ribosome-Sec61 complex. Cold Spring Harbor Symposia on Quantitative Biology 66, 543-554. PMID: 12762056; PMCid:
Frank, J., Penczek, P., Grassucci, R.A., Heagle, A., Spahn, C.M.T., and Agrawal, R.K. (2000). Cryo-electron microscopy of the translational apparatus: Experimental evidence for the paths of mRNA, tRNA, and the polypeptide chain. In The Ribosome: Structure, Function, Antibiotics, and Cellular Interactions, R.A. Garrett, S.R. Douthwaite, A. Liljas, A.T. Matheson, P.B. Moore, and H.F. Noller, eds. (Washington, DC, ASM Press).
Frank, J., Penczek, P., Agrawal, R.K., Grassucci, R.A., and Heagle, A.B. (2000). Three-dimensional cryoelectron microscopy of ribosomes. In Three-dimensional cryoelectron microscopy of ribosomes, D.W. Celander, and J.N. Abelson, eds. (San Diego, CA, Academic Press), pp. 276-291.
Frank, J., Agrawal, R.K., and Verschoor, A. (2000). The structure of the ribosome. In Encyclopedia of Life Sciences (Macmillan Press), p. Article No. A534.
Frank, J., and Agrawal, R.K. (2000). Bacterial ribosomes. In Encyclopedia of Life Sciences (Macmillan Press), pp. Article No. A305, http://www.els.net/elsonline/html/A0000305.html.
Frank, J., and McEwen, B.F. (1992). Alignment by cross-correlation. In Electron Tomography, J. Frank, ed. (New York, Plenum), pp. 205-213.
Frank, J. (1992). Introduction. In Electron Tomography, J. Frank, ed. (New York, Plenum), pp. 1-13.
Frank, J., Radermacher, M., Wagenknecht, T., and Verschoor, A. (1988). Methods for studying ribosome structure by electron microscopy and computer image processing. In Methods in Enzymology K. Moldave, ed. (New York, Academic Press), pp. 3-35.
Frank, J., and Radermacher, M. (1986). Three dimensional reconstruction of biomolecular assemblies. In Advanced Techniques in Biological Electron Microscopy J.K. Koehler, ed. (Berlin, Springer Verlag), pp. 1-72.
Frank, J., Verschoor, A., and Wagenknecht, T. (1985). Computer processing of electron microscopic images of single macromolecules. In New Methodologies in Studies of Protein Conformation, T.T. Wu, ed. (New York, Von Nostrand Reinhold, Inc.), pp. 36-89.
Frank, J. (1980). Introduction to quantitative methods of reconstruction. In Methods and Perspectives in Cell Biology: Three Dimensional Ultra-Structure in Biology, J.N. Turner, ed. (New York, Academic Press), pp. 325-344.
Frank, J. (1980). Introduction to quantitative methods of reconstruction. In Methods and Perspectives in Cell Biology: Three Dimensional Ultra-Structure in Biology, J.N. Turner, ed. (New York, Academic Press), pp. 199-213.
Frank, J. (1980). The role of correlation techniques in computer image processing. In Computer Processing of Electron Micrographs P.W. Hawkes, ed. (Heidelberg, Springer Verlag), pp. 187-222.
Frank, J. (1973). Use of anomalous scattering for element discrimination. In Image Processing and Computer-Aided Design in Electron Optics, P.W. Hawkes, ed. (New York, Academic Press), pp. 196-211
Frank, J. (1973). Computer processing of electron micrographs. In Advanced Techniques in Biological Electron Microscopy, J.K. Koehler, ed. (Heidelberg, Springer Verlag ), pp. 215-274.
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